Associate Medical Director, Translational Neuromedicine

The Quantitative Medicine and Clinical Technologies (QMCT) group applies a quantitative neurological model to incorporate multi-scale computational modeling and simulation to bring specific value to development and discovery; catalyzing the organization towards a human-centric transformative quantitative biology strategy for drug development / discovery. QMCT includes platforms in clinical technologies (including digital and internet of things approaches), quantitative medicine and experimental medicine and relies on robust interfaces with groups across Biogen.

The Quantitative Medical Scientist is part of an industry leading group that focuses on defining the ideal use and research path for the use of exploratory experimental human medicine within the R&D organization and in the enterprise. This group will conduct high impact, hypothesis-driven exploratory science in human subjects and defined patient populations. Its goal is to explore and integrate clinical and pre-clinical measurements and models enabling the clinic as a laboratory that informs pre-clinical experimentation and supports and enhances clinical trial design drug development. Using human and clinical data to drive a successful translational science cycle from patient to laboratory and into clinical trials is consistent with the Quantitative Medicine approach.
This team will deliver an innovative strategy (the Quantitative Medicine Plan) and compelling human data that tests focused hypotheses in patients and human subjects aimed at understanding core features of neurologic and psychiatric disease. Evaluation and development of new methods, computational strategies and the application of multi-factorial transforms to translate between human biology, pre-clinical experimentation and clinical trial end-points will be a focus of the team.

Accountability:
• To work as a member of a cutting edge human biology team focused on experimental medicine.?Conduct human studies to understand the underlying pathophysiology of diseases of interest.
• Be the QM Point of Contact for several portfolio teams. Utilize known pathophysiology and latest knowledge of human brain function and behavior to provide early assessment of efficacy of clinical measurement candidates.?Utilizes human brain imaging, cognitive testing and creative psychophysical measurements to test hypotheses in humans.
• Assist and implement in the delivery of mulitscale computational human biology and disease models that provide a platform for translating human biology to drug discovery.?Leverage human genetics, -omics and known human pharmacology under the auspices of 'Precision medicine' to identify and target stratified patient populations.

• Minimum 10 years neuroscience clinical experience including patient care and research.
• Experience in pharmaceutical drug discovery R&D environment with experience in discovery, early clinical development or in late stage development a plus.
• Demon

The Associate Medical Director will be a Quantitative Medical Scientist and a member of the Translational Neuromedicine line, whose purpose is to provide Biogen with a systems science approach for the quantification of the health state of patients and provide a rigorous paradigm for improving clinical trial outcomes in neuroscience diseases.