Principal Scientist, Precision Medicine Strategy Lead (Clinical Biomarkers)

We are seeking a Precision Medicine Strategy Lead (PMSL) at the Principal Scientist level responsible for the clinical biomarker strategy for multiple clinical stage assets in Regeneron's Immunology & Inflammation (I&I), Ophthalmology and Infectious Diseases portfolios.

The successful candidate will be motivated and innovative in their proposals for clinical biomarker strategies that drive the success of both early and late-stage clinical programs. They will be knowledgeable regarding key literature and relevant technologies. They will thrive in a collaborative environment and regularly partner with research teams, clinical development, laboratory operations, companion diagnostics, clinical operations, tech centers, alliance partners, external academic collaborators, and others. They will be exceptional communicators as they routinely present their strategy, rationale and data to senior leaders.

This is a high-impact, highly visible role at the intersection of science and strategy in Regeneron’s Translational Medicine organization. The work done as a Principal Scientist will enable endpoint selection, choice of clinical indication, and demonstration of target engagement, early signs of activity, mechanism of action and patient stratification/selection.

As a Lead, a typical day may include:

• Define and champion the strategic vision and scientific rationale for clinical biomarker plans supporting one or more programs in I&I, Ophthalmology, and/or Infectious Disease

• Serve as a Precision Medicine representative on clinical development teams, driving biomarker strategy from initial concept through execution, data delivery, and interpretation.

• Partner with clinical and laboratory operations to implement biomarker and exploratory sample collection and analyses

• Ensure clinical biomarker assays are fit-for-purpose — whether developed internally or through external collaborators/CROs

• Present translational project plans, biomarker data, and results to internal and external stakeholders, including senior leadership

• Contribute to the highest-quality Precision Medicine content in clinical protocols, study reports, data reviews, biomarker reports and manuscripts/publications

This role might be for you if can: ​

• Translate complex immunology and disease biology into clear, testable clinical biomarker hypotheses and decision criteria.

• Lead cross-functional teams to design, operationalize, and troubleshoot end-to-end biomarker plans across global studies.

• Drive fit-for-purpose assay development and validation with internal labs and CROs, balancing scientific rigor, cost, and timelines.

• Synthesize and communicate biomarker insights into compelling narratives for diverse stakeholders, including senior leadership, to inform key decisions.

• Navigate ambiguity, prioritize across multiple programs, and foster a collaborative, innovative culture in a matrixed environment.

To be considered for this role, you must have:

• Ph.D. with post-doctoral experience in Immunology or closely related field is highly desirable

• 5+ years of relevant experience in pharmaceutical/biotech industry research and/or translational clinical development

• Exceptional communicator with strong emotional intelligence and enthusiasm for presenting to senior leaders

• Collaborative, innovative, and energized by working in a matrixed environment

• Understanding of biomarker strategy in clinical development, including assay development, validation, and implementation with a track record of high-impact contributions to drug development programs is a huge plus

• Experience authoring industry documents (protocols, CSRs, biomarker reports) is a plus

• Alternative levels will be considered commensurate with experience

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all  qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate.  The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.  Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.  If you have any questions, please speak with your recruiter. 

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)