Research Technician

The Xu Lab at the Center for Retrovirus Research at The Ohio State University is seeking a highly motivated Research Technician to support cutting-edge research in vaccine design and antibody therapeutic discovery. This is a long-term position (expected commitment of >3 years) for a dedicated and reliable laboratory professional. This position is subject to a 6-month probationary period, during which performance, technical skills, and laboratory fit will be evaluated prior to continuation of long-term appointment. The primary responsibility of this role is to support the laboratory’s protein production pipeline, with a strong focus on molecular cloning and recombinant protein purification. The successful candidate will play a key role in generating high-quality protein reagents that support our research, with opportunity to contribute to high-impact publications and translational research programs. 

Key Responsibilities:

• Design, perform, and optimize molecular cloning for recombinant protein and antibody expression constructs.  

• Conduct protein expression and purification in bacterial, insect, and mammalian systems. 

• Operate and maintain chromatography systems (e.g., ÄKTA/FPLC) for multi-step purification workflows.  

• Optimize expression constructs and purification conditions to improve protein yield, purity, and stability.  

• Maintain detailed, accurate, and reproducible experimental records.  

• Manage laboratory reagents, inventory, and general laboratory organization.  

• Provide consistent technical support to postdoctoral fellows and graduate students. 

Working Conditions:

• Bachelor’s degree in Biochemistry, or a related field. 

• Hands-on experience in molecular cloning and recombinant protein expression/purification. 

• Strong understanding of molecular biology and protein biochemistry principles. 

• Excellent attention to detail and strong commitment to reproducibility and high-quality experimental work. 

• Ability to work independently and as a reliable member of a collaborative team. 

• Strong commitment to a long-term position (≥3 years) with stability and continuity in laboratory support work. 

• Excellent organizational skills, attention to detail, and strong teamwork and communication abilities.  

• Ability to manage multiple ongoing tasks. 

• Proven track record of successful laboratory work in protein expression, purification, and related molecular biology/biochemistry techniques.  

Target Salary Range: $15.86 - $20.74 per hour; commensurate with experience, internal equity, the unit’s available budget, and the candidate’s qualifications.