Co-op Student, ADME/DMPK

What You'll Do

• The student is expected to participate in the design, validation, and implementation of ADME/DMPK assays to profile new drugs, drug-linkers, and antibody-drug conjugates: 
• Implements and validates DMPK protocols for the characterization of new payloads and drug-linkers. For example:  
• • Plasma stability 
  • Lysosomal stability  
  • Kinetic solubility  
  • Plasma protein binding (PPB) 
  • Lysosomal trapping 
  • In vitro drug metabolism in different biological matrices 
• Prepares samples (tissue preparation and extraction of analytes) for LC-MS analysis.  
• Quantify drugs and/or drug metabolites using LC-MS/MSMS/HRMS and conducts data analysis using excel and GraphPad Prism.  
• Performs experiments, interprets, and analyzes data, and prepares presentations for group meetings 
• Administrative duties such as contributing to the writing of Standard Operation Procedures (SOPs) 
• Conducts all activities in accordance with scientific standards, OS&H regulations, and established Zymeworks policies and practices 
• Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic notebook 
• Contributes to a safe and highly efficient laboratory environment through ordering of consumables, regular maintenance of reagent inventory, preparation of solutions, stocking of consumables, and maintaining a clean working environment 

What You'll Bring

• Currently enrolled in an undergraduate program in Chemistry, Biochemistry, or Biotechnology. 
• Availability for an 8-month co-op term is required. 
• Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships 
• Good organizational skills and the ability to work effectively in a high-paced, fast-changing environment. Results-oriented mindset  
• Experience with in vitro assays is preferred 
• Experience with characterization of small molecules using HPLC-MS and some familiarity with operating these instruments outside of the teaching lab is preferred 
• Excellent oral and written communication capabilities 
• Good computer skills particularly with MS Office suite and ChemOffice (ChemDraw) 

Why Work for Us?

Zymeworks’ employees are passionate, engaged and extremely motivated to succeed. We are excited by the cutting-edge science and technology, the endless possibilities this union holds and the sheer opportunity to be a part of something big.  

As a Co-op Student, you’ll get to work directly with the teams to learn and contribute to creating the best-in-class therapeutics.  Our Co-op Program is designed to challenge students to think critically by actively participating in projects, and to develop professionally and personally.  

Our competitive program makes your time at Zymeworks worthwhile.  

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.  

NOTE TO AGENCIES:  Zymeworks values our relationships with our recruiting partners. We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.