Principal Scientist II Bioinformatics - Hiring Now

We are searching for a persistent Principal Scientist II Bioinformatics to join our energetic team at F. Hoffmann-La Roche Ltd in Mississauga, ON.
Growing your career as a Full Time Principal Scientist II Bioinformatics is an incredible opportunity to develop key skills.
If you are strong in leadership, critical thinking and have the right mindset for the job, then apply for the position of Principal Scientist II Bioinformatics at F. Hoffmann-La Roche Ltd today!

The Position

Roche Sequencing Solutions (RSS), a business within Roche Diagnostics, focused on developing a disruptive Next-Generation Sequencing (NGS) platform along with a portfolio of reagents, assays and informatics solutions for multiple disease areas. We are looking for a Principal Bioinformatics Scientist in the NGS Algorithms and Applications team to support the algorithm development efforts.

In this role, you will collaborate closely with assay scientists, software engineers and other bioinformatics scientist and apply your strong knowledge in next generation sequencing technologies. This will include illumine SBS (sequencing by synthesis), nanopore, etc. to design and develop algorithms for read processing, alignment, and variant (SNV, SV, insertions/deletions, CNV, TMB, MSI) callers etc. This will be used in our products that will affect patient care.

Responsibilities:

• Lead algorithm development effort for NGS applications including conceptualization, method development and implementation of production level algorithms in an Agile environment.

• Follow software development process and deliver and maintain documentation that explains why and how as well as the final design for scientific, marketing, and regulatory uses

• Present internally or externally (peer-reviewed publications or conference proceedings) and communicate updates across multiple functions in the organization. Transfer algorithm to production teams and provide scientific support for updates and maintenance

• Support bioinformatics pipeline to continue development for existing products

Qualifications:

• PhD in Bioinformatics, Computational Biology, Computer Science, Statistics, Mathematics or other quantitative field combined with 2 - 6 years of experience of designing novel algorithms for NGS data analysis for example read processing, variant calling (SNV, insertions/deletions, CNV, SV, TMB, MSI etc.), variant annotation and analyzing large scale complex genomic datasets.

• Experiences in developing novel algorithms, complexity analysis, as well as demonstrated skillset in statistical and mathematical modeling is a Must.

• Experience implementing high-quality and efficient product level code.

• In depth knowledge of sequencing (long and/or short read), cancer molecular biology, bioinformatics tools, statistical methods.

• Proficient with programming languages (C++ and/or Python) in a distributed Linux environment

• Experience with Machine learning / Deep learning (used in NGS context) is a plus.

• Hands-on experience using a workflow management system such as Nextflow or Snakemake, using Docker and cloud computation resource and storage

• Strong written and verbal communication skills with ability to adjust to technical and non-technical audiences

• Result-oriented individual that thrives in collaborative multi-disciplinary teams. Excels at incorporating feedback in a professional manner.

• One or more first/co-first author publication(s) in a high-impact peer reviewed journals is highly desired.

Relocation assistance is not available for this role.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche Pharma Canada has its office in Mississauga, Ontario and employs over 850 employees. The Mississauga facility is bright, vibrant, fosters collaboration and teamwork, and is reflective of Roche's truly innovative culture.

As of January 4, 2022, Roche requires all new employees who work in Canada to be fully vaccinated against COVID-19 on the date they take office. This requirement is a condition of employment at Roche that applies regardless of whether the position is on a Roche campus or remotely. If you have a valid reason for not being fully immunized, which is limited to certain specific medical reasons or other valid reasons protected by applicable human rights laws, you may request an exemption and / or adaptation measures regarding this vaccination requirement.

Roche is an Equal Opportunity Employer.

Benefits of working as a Principal Scientist II Bioinformatics in Mississauga, ON:

● Excellent Benefits Package
● Rapid Progression
● Advantageous package