Principal Scientist, ADME RLT

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

About POINT Biopharma:

POINT Biopharma Global Inc. is a globally focused radiopharmaceutical company building a platform for the clinical development and commercialization of radioligands that fight cancer. Recently acquired by Eli Lilly and Company, POINT aims to transform precision oncology by combining a portfolio of targeted radioligand assets, a seasoned management team, an industry-leading pipeline, in-house manufacturing capabilities, and secured supply for medical isotopes including actinium-225 and lutetium-177. POINT is a wholly owned subsidiary of Eli Lilly and Company.

Position Summary:

Reporting to the Vice President, Discovery and Translational Sciences, the Principal Scientist of ADME will be responsible for the analysis of new candidate radioligands that are being developed as part of POINT’s discovery pipeline. This role will involve establishing and performing analytical methods to profile the distribution, metabolism, and clearance of experimental pharmaceuticals being tested in vivo and in vitro. The ideal candidate will have technical experience with inductively coupled plasma analyzers, liquid chromatography/mass spectrometry analysis methods, familiarity with handling and analysis of biological samples, and experience working with radioactive materials. We are searching for a motivated and enthusiastic scientist who possesses these skills and has an appreciation and understanding of in vivo pharmacology and the drug discovery process.

Roles and Responsibilities of the Position:

• Independently plan and perform chromatography and MS-based analysis of samples to assess biodistribution of candidate therapeutics.
• Perform metabolite profiling of biological samples (serum, tissues, urine, etc) using mass spectrometry for both non-radioactive and radioactive ligands.
• Develop and validate methods to quantitatively determine amounts of heavy metals in animal tissue sections using ICP-MS.
• Optimize and perform appropriate digestion methods and sample preparation for ICP-MS experiments.
• Develop methods to quantify ligands in biological samples using radiometric LC/MS or related approaches.
• Plan and perform research work both independently and with the guidance of senior scientists, working cross-functionally to support discovery and preclinical activities.
• Proactively carry out routine maintenance of analytical equipment to ensure consistent and high-quality data collection.
• Critically assess data and methods, maintain accurate records of experimental details, and generate SOPs.
• Provide clear communication of scientific data and project status to co-workers through internal presentations and written methods.
• Manage time effectively and establish priorities to meet timelines for key experiments across multiple projects.
• Support evaluation of late-stage assets as necessary.
• Maintain a safe working environment for themselves and others through full compliance with health and safety protocols and regulatory requirements governing the use of radioactive materials.

Required Qualifications:

• Minimum M.Sc. in chemistry, biochemistry, chemical biology, pharmacy, or related discipline.
• Minimum 5 years relevant postgraduate experience.
• Demonstrated success and direct experience developing mass spectrometry based analytical methods.
• Experience with research and analysis of radioactive materials.
• Familiarity and experience with inductively coupled plasma ionization methods and their application to mass spectrometry (ICP-MS).
• Experience performing quantification and analysis of biochemical/biological samples.
• Understanding of drug properties and in vivo behaviour (PK/PD, ADME, and principles of medicinal chemistry).
• Ability to communicate scientific data effectively to an interdisciplinary team.
• Excellent problem-solving and decision-making skills.
• Working knowledge of MS-Office, Graphpad Prism, and ChemDraw.

Additional Preferences:

• Ph.D. in chemistry, biochemistry, chemical biology, pharmacy, or related discipline.
• Industry experience is preferred.
• Prior experience with in vivo pharmacology is a strong asset.
• Knowledge or experience with radiopharmaceuticals and GLP/GMP protocols is an asset.

Physical Demands/Travel:

• Work environment is onsite downtown Toronto near College Street and University Avenue at the MaRS building.
• Anticipate travel for team and client meetings. Traveling across borders may be required, proper travel documentation such as a valid passport and travel visas are required.
• Wear standard PPE in the lab is required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

• Must have use of full dexterity to perform routine tissue culture, benchwork, etc in a laboratory setting.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Eli Lilly Canada is committed to employment equity. We encourage applications from qualified women, members of visible minorities, aboriginal peoples, and persons with disabilities.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [email protected] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( [email protected] ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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