Experimental Biology Internship / Stage biologie moléculaire

A51 is a biotech start-up developing programmable RNA to modulate cellular states in health and disease. Backed by top-tier Silicon Valley VC and based at the PC’UP deeptech incubator in the heart of Paris, A51 is a winner of the national i-Lab innovation competition and part of the 2025 Future 40 cohort, a recognition that places A51 among the top 4 percent of start-ups.

We are committed to making biology engineerable by rapidly designing functional RNAs that modulate cell behaviour. Beyond treating disease, this opens the door to regenerative medicine and real-time cellular reprogramming. We are a global, ambitious, and interdisciplinary team spanning wet lab, computation, AI, and engineering, working on one of the most promising technologies in biotech.

Your responsibilities will include:

• Running molecular biology workflows (PCR, cloning, gel electrophoresis, sequencing, sample prep)
• Working with bacterial strains and mammalian cells containing computational RNA circuits
• Operating and analysing experiments using FACS, fluorescence microscopy, and other imagingbased screens
• Running Oxford Nanopore sequencing workflows from end-to-end including library prep and barcoding strategies
• Contributing to experimental design with molecular-, cell-, and computational biology, and microfluidics scientists
• Maintaining orderly lab notebooks and participating in team discussions around data and strategy

What you bring:

• Currently enrolled in Bachelor’s (Licence) or Master’s program, engineering school, or equivalent program in Biology, Biotechnology, Bioengineering, or a related field
• Hands-on experience with basic molecular biology techniques (PCR, gel electrophoresis, cloning, sequencing), bacterial or mammalian cell culture
• Interest in imaging techniques based on fluorescence like fluorescence microscopy and cytometry
• Curiosity, rigor, willingness to learn, and comfort working in a fast-moving environment
• Ability to communicate in English (French is a plus)

Nice to have:

• Experience with primary data analysis and molecular cloning (Matlab, Python, Fiji, FlowJo, Geneious)
• Exposure to cell biology, synthetic biology, gene circuits, and phenotypic screening
• Prior internship in an experimental lab or a biotech company

What you will learn:

• How to run end-to-end experimental workflows bridging computation and wet lab
• How biological circuits can be engineered, screened, and optimized to program biology
• How to design and execute high-throughput experiments and analyze sequencing based and fluorescence imaging based readouts
• How early-stage biotech start-ups build technology, test hypotheses, and move fast without sacrificing rigor

Compensation and start date:

• Paid internship per French standards
• Start date in February 2026 for a 3-6 month period

How to apply?

Email your CV and a short motivation note on why you want to work at A51 to [email protected]