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Expert GPCR Cellular Assays (GN)

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Arbeitsbeschreibung - Expert GPCR Cellular Assays (GN)

  • Contribute to multidisciplinary and challenging research projects in the field of drug discovery.
  • Provide expert knowledge in GPCR biology, focusing on GPCR/G-protein interactions and ligand pharmacology.
  • Independently design, execute, and interpret cellular functional assays for profiling and classifying ligands based on their mode of stimulation.
  • Develop and apply fluorescence and luminescence assays with continuous kinetic readout on FLIPR or FDSS workstations.
  • Perform ligand screening in HTS mode and ligand profiling experiments.
  • Utilize cell culture techniques and select relevant cell lines.
  • Ensure compliance with industry standards for screening, profiling, and characterization of ligand–GPCR binding.
  • Maintain thorough documentation of work according to internal guidelines and customer requirements using a laboratory management system (LIMS).
  • Ph.D. in cell biology, pharmacology, biochemistry, or a related field, with a strong focus on membrane protein signaling.
  • At least 3 years of experience in a drug discovery environment, covering the process from screening to lead identification.
  • Deep understanding of GPCR pharmacology and G-protein interactions.
  • Hands-on experience with FLIPR or FDSS workstations
  • Proven expertise in other fluorescence- and luminescence-based GPCR assay technologies, such as TR-FRET, FRET, nanoBRET.
  • Strong analytical and problem-solving skills with a high level of accuracy and attention to detail.
  • Ability to work independently and in interdisciplinary teams across different projects.
  • An innovative professional field in an exciting industry
  • An inspiring working atmosphere as fertile ground for your further development
  • A comprehensive induction that prepares you optimally for your area of responsibility
  • Multicultural teams and an open corporate culture
  • A salary in line with the market

Proteros biostructures GmbH
 People Team
 Bunsenstr. 
7a, 82152 Martinsried
 +49 89 700761-0
 [email protected]

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