Master Thesis Project (m/f/d) Tumor Cell Plasticity Group

The Tumor Cell Plasticity Group, part of the Robert Bosch Center for Tumor Diseases (RBCT) (https://www.rbct.de/en/tumor-cell-plasticity), is based at the Bosch Health Campus in Stuttgart, adjacent to the Robert Bosch Hospital (RBK). As a translational cancer research institute affiliated with the National Center for Tumor Diseases (NCT) Southwest and the Comprehensive Cancer Center Tübingen-Stuttgart, the RBCT supports cutting-edge research dedicated to advancing cancer therapy.

Our research team investigates how transcriptional programs shape cancer cell identity and behavior. Using state-of-the-art techniques—such as genome-wide and transcriptome profiling, single-cell RNA sequencing, high-throughput functional screens, and precise genetic manipulation in cancer cell systems—we aim to uncover gene regulatory networks that drive tumor plasticity. Ultimately, our goal is to pinpoint novel molecular targets that could be harnessed to enhance therapeutic efficacy and improve patient care.

Master’s Thesis Project: Scope and Responsibilities

As part of your thesis, you will:

• Apply sequencing-based molecular biology techniques (e.g., RNA-seq, ChIP-seq, HiChIP, Hi-C, PRO-seq) to investigate gene regulation and epigenetic mechanisms in cancer.
• Perform bioinformatic analysis and interpretation of high-throughput data to generate and test biological hypotheses.
• Conduct advanced cell culture experiments, including drug treatment studies in diverse cancer models.
• Use CRISPR/Cas9 gene editing to generate and analyze genetically modified cell lines.
• Participate in high-throughput compound screening in engineered models.
• Engage in internal and external collaborative research projects.
• Document experimental protocols, data acquisition, and analysis results systematically.

We are looking for a highly motivated Master’s student who:

• Is currently enrolled in a Master of Science program (e.g., Biology, Molecular Biology, Molecular Medicine, or a related field).
• Has practical experience with cell culture, transfection techniques, and standard molecular biology methods (e.g., qPCR, Western blotting).
• Possesses a basic understanding of sequencing data and a strong interest in bioinformatics and data-driven biology.
• Works independently, is goal-oriented, well-organized, and thrives in a team environment.
• Communicates confidently in written and spoken English.
• Is passionate about contributing to cancer research and making a meaningful impact.
• Non-EU applicants will only be considered if they have already secured funding for their stay

What We Offer:

• A dynamic and international research environment
• Extensive expertise in cutting-edge epigenetic and gene regulatory techniques
• Access to robust bioinformatics support
• State-of-the-art infrastructure for project-related methods
• A collaborative and supportive lab culture
• Long-standing expertise in cancer biology and transcriptional regulation (https://pubmed.ncbi.nlm.nih.gov/?term=najafova+z&sort=pubdate&size=20)

Contact:

Dr. Zeynab Najafova

Group Leader Tumor Cell Plasticity Group

E-mail: [email protected]

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