Scientist: Bioconjugation and Diagnostic Assay Development (m/w/d)

Nanogami is a highly innovative and rapidly growing startup in the field of DNA Origami-based nanotechnology (check out our DLD Talk or this article to learn more). Our international team is driven by a shared vision: to pioneer a novel generation of biochips set to unlock applications in research and diagnostics and thereby pushing the boundaries of personalised medicine to new heights. We recently secured significant funding by SPRIND - Germany’s Federal Agency for Disruptive Innovation to realize our ambitious growth trajectory and now aim to significantly expand our current team to support the at-scale commercialisation of our nanotechnology.

Join us as Bioconjugation & Diagnostics Assay Development Scientist (m/w/d) to help shape the future of proteomics.

You will be working in cross-functional teams to develop and optimize protein bioconjugation and DNA origami surface immobilization strategies. You'll own your experiments end-to-end, using covalent binding methods and biophysical tools like AFM, optical microscopy, and mass photometry to analyze and refine your work.

Your Role:

• Independently develop and optimize protein bioconjugation strategies, with a focus on protein-DNA and protein-small molecule conjugates, particularly involving antibodies.
• Develop and set up the coupling and immobilization protocols of protein-DNA conjugates, with a focus on antibodies
• Set up systems and workflows for purification, characterization and functional assays of custom nanostructures functionalised with various proteins, in particular antibodies
• Stay up-to-date with state-of-the-art assay technology and share expertise with various project teams
• Collaborate with a multidisciplinary team of scientists and engineers to optimize biochip performance
• Manage R&D projects with a high level of autonomy and initiative, within the constraints of a start-up environment

• Ph.D. (or M.Sc. with extensive industry experience) in Chemistry, Biochemistry, (Molecular) Biology, or a related field.
• Extensive expertise in bioconjugation of proteins, in particular antibodies, to DNA or small molecules in the context of assay development
• Proficiency in purification, characterization and functional assays of proteins and protein conjugates using techniques such as affinity chromatography, IE-HPLC, SEC, Western Blots and various activity assays.
• Creative, proactive, and results-oriented mindset.
• Excellent interpersonal and communication skills.
• Fluent in English.

Optional:

• Industry experience in e.g. ELISA assay development, ideally in the context of medical diagnostics
• Proficiency in bioconjugation to surfaces and/or nanoparticles
• Experience in designing, production or characterization DNA nanostructures

• Shape the future of diagnostics - be at the forefront of the development of our products
• State-of-the-art technology package.
• Accelerated career trajectory.
• Competitive compensation and benefits structure.
• An international, collaborative, and supportive work culture.
• Flexible working models.