Associate Research Scientist/Scientist - Biology

Ph.D with Postodoctoral or Masters with 5+ years of hands-on experience in cell-based assay development and troubleshooting skills; ability to handle different plate formats for small molecule screening 

Reporting to senior team leader, work with a group of in vitro assay biologists, learning and coaching group members to improve skills and productivity 

Independently design, conduct, optimize and proactively troubleshoot assays 

Develop, optimize and validate biochemical and cell-based assay platforms for the hit identification, lead optimization and functional characterization of small molecules 

Work on the bench implementing state-of-the-art technologies for the different assay platforms 

Ensure robust and high-quality assays with efficient use of automation and instrumentation 

Data processing, interpretation and presentation to cross functional team members 

Proposing, planning, quoting, tracking reagent needs, usage and executing timelines for each study 

Work closely with other biology groups involved in screening, cell biology, protein biology and ADME, offering integrated drug discovery support alongside chemistry for multiple client-based projects

Extensive work experience in cell biology and biochemistry techniques 

Good working knowledge of transcription-based studies, targeted protein degradation, target identification and validation 

Cell culture experience and in handling different immortalized cell lines, primary cultures, 3D cultures 

Ability to perform transient transfections and generate stable cell lines  

Good working knowledge of immunoprecipitation and Western blotting for protein analysis, quantification and in studying protein-protein interactions 

Experience in fluorescence microscopy and high-content imagining is an advantage  

Experience in targeted protein degradation, target engagement assays (e.g. nanoBRET, CETSA) is an advantage 

Experience in CRISPR-CAS9 knock-out and siRNA/shRNA knock-down studies  

Experience with site-directed mutagenesis is beneficial but not a must  

Candidates must be capable of excellent teamwork in a fast-paced, multidisciplinary environment, where meeting timelines will be essential. 

 Excellent data analysis and interpretation skills

An ability to overcome technical challenges and exercise sound judgment under pressure  

High self-motivation to initiate projects and work independently under aggressive deadlines 

A strong technical knowledge with exceptional attention to detail 

An excellent personal rapport and an ability to engender trust and respect 

An ability to work well as part of a small focussed team and build relationships 

An exceptional communication skill and an ease in interaction with all stakeholders

An infectious enthusiasm for life, work and making a difference to the world in which we live 

A bright, friendly, flexible personality with agility to switch between different skill sets 

An exceptional organisational skill that thrives working in a fast-paced and vibrant team environment 

Positivity, focus and a winning mentality allied with kindness 

Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture