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Research Associate/Senior Research Associate - Peptide/High Potent APIs (HPAPI)/Organic/Antibody Dru

Job Description - Research Associate/Senior Research Associate - Peptide/High Potent APIs (HPAPI)/Organic/Antibody Dru

Job description

High Potent APIs (HPAPI):

  • Perform hands-on laboratory chemistry activities involving high-potency APIs / potent compounds.

  • Execute chemical reactions, work-ups, purification and related laboratory processes.

  • Handle HPAPIs in accordance with applicable safety, containment and handling procedures.

  • Maintain accurate laboratory records, experimental data and documentation.

  • Support process development, optimization and troubleshooting activities.

  • Perform analytical sample preparation and coordinate with analytical teams as required.

  • Follow established GMP, EHS and laboratory safety requirements.

  • Support investigation and resolution of laboratory/process-related issues.

  • Where required, support chemistry activities related to ADC and highly potent payloads.

  • Work effectively with cross-functional teams including analytical and other chemistry groups.

Organic Chemist:

  • Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance

  • Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography

  • Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations

  • Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately

Peptide Chemist:

  • Hands-on expertise in solid-phase and solution-phase peptide synthesis using automated synthesisers like Syro and Liberty CEM

  • Strong experience in peptide purification, characterisation, and analytical techniques, including HPLC, LCMS, and MS

  • Capable of independently handling medium- to large-scale peptide synthesis (1 g to 1 kg scale) with troubleshooting abilities

  • Skilled in laboratory operations, equipment maintenance, SHE compliance, literature review, and accurate experimental documentation

Scaleup Chemist:

  • Experience in process R&D, scale-up synthesis, and purification from gm to kg scale

  • Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities

  • Proficient in 1H NMR, HPLC, and LCMS interpretation

  • Strong project execution and team collaboration skills

Antibody Drug Conjugation Chemist (ADC)

  • Synthesis and purification of complex antibody drug conjugate (ADC) molecules

  • Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs

  • Synthesis of highly potent drug molecules – payloads

  • Purification of complex and large molecules by flash column and HPLC

  • Handling various type chemistry with different payloads

  • Interpretation and characterisation of higher molecular weight compounds

Job requirements

Principal Scientist;

  • PhD/MSc in Organic Chemistry / Medicinal Chemistry or related field.

  • Strong experience in CRO/CDMO research environment.

  • Proven team management experience with exposure to handling multiple projects.

  • Excellent communication and client-facing skills.

  • Ability to drive productivity, scientific excellence, and team development.

Organic Chemist:

  • Master’s in Organic Chemistry with 1-3 years of experience in the CRO Industry
    Strong organisational, project management and problem-solving skills with impeccable multi-tasking abilities.

  • Proactive, highly motivated with a "can do" attitude

  • Exceptional interpersonal skills.

Peptide/Scaleup/Antibody Drug Conjugation (ADC) Chemist:

  • Master’s in Organic Chemistry with a minimum of 2 years and a maximum of 6 years of experience in the CRO/API Industry

  • Adherence to safe practices and procedures

  • Contribution to the development of safety protocols and systems

  • Must be able to prioritize and organize work responsibilities in order to meet deadlines

Original job Research Associate/Senior Research Associate - Peptide/High Potent APIs (HPAPI)/Organic/Antibody Dru posted on GrabJobs ©. To flag any issues with this job please use the Report Job button on GrabJobs.
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About the Company

O2h Group

o2h group has a track record of nurturing and investing in emerging life science and tech companies, covering biotech, small molecule, biologics, digital health, software and green innovation.

Read more about the company

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