TD And E - TD - PMO Lifescience - Manager

Transformation Design & Execution

The Transformation Design & Execution practice @ EY provides a rewarding career opportunity, targeted toward becoming a professional in complex business, technology and infrastructure transformation. If you have a passion for rallying together to solve the most complex challenges in today’s marketplace. Within Life Sciences & Healthcare, we support leading biopharma, MedTech, and CRO clients across the R&D, regulatory, quality, manufacturing, and commercial value chain to deliver transformation programs that operate effectively within complex, GxP-regulated environments.

Role

As a Manager, you will lead end-to-end workstreams with US and global teams to deliver large-scale transformation programs for Life Sciences clients. You’ll contribute your sector expertise and consulting skills to help design PMO/EPMO/Transformation Office capabilities, strengthen program and portfolio delivery, and enable data-driven decision-making.

This role is ideal for professionals with deep Life Sciences sector and value chain expertise and proven consulting experience - those who can combine strategic thinking, delivery leadership, and client engagement to deliver measurable outcomes. In addition to delivery leadership, you’ll support and grow a skilled team experienced in planning, controlling, and executing transformation initiatives. You’ll also engage in strategic conversations with clients, helping to identify opportunities for EY to add value and contribute to business development.

Key Responsibilities

Strategy & Solution Design

• Translate corporate strategy into phased transformation roadmaps, target operating models, and investment cases across R&D, clinical, manufacturing, and commercial functions.


• Work with technical teams to design custom solutions that align with client’s needs and fit the specific context of their organization.


• Design compliant-by-default solutions with fluency in GxP, data integrity, and change control.

Assessment, Planning & Value Realization

• Develop project plans with timelines, milestones, dependencies, and resource allocation.


• Conduct needs assessments to identify gaps and opportunities for improvement.


• Evaluate process, data, technology, talent, and control maturity using structured frameworks and benchmarks.


• Construct value trees linking use cases to drivers (cycle time, yield, cost-to-serve, quality, compliance risk), defining baselines, KPIs, and a benefits ledger with ownership and verification methods.


• Design sourcing models and govern vendor relationships (CROs, CDMOs, platforms, SI partners).

Implementation & Delivery

• Oversee deployment, configuration, and integration of solutions including data migration and system setup.


• Stand up product-centric portfolios, run agile-at-scale, manage dependencies and risks, and integrate PMO discipline.


• Conduct testing and quality assurance of solutions to ensure functionality and resolve issues pre-launch.


• Monitor solution performance and gather feedback for continuous improvement.

Change Enablement & Communication

• Lead change management strategies including communications, training, role design, and incentives.


• Facilitate large-format workshops (discovery, future-state design, prioritization) with visual synthesis and storytelling.


• Act as liaison between clients and technical teams to ensure clear communication and alignment.


• Develop communication strategies to manage stakeholder engagement and resistance to change.

Governance, Documentation & Digital Literacy

• Map and align executive sponsors and functional leaders under clear governance and decision rights.


• Maintain documentation including user manuals, training materials, and project reports.


• Demonstrate literacy in data models, master data, interoperability, cloud platforms, validated systems, and genAI/analytics productization.


• Apply controls for safety, bias, privacy, and traceability in digital solutions.

Technology & Data Enablement

• Oversee configuration and integration of PPM tools (e.g., Planview, Clarity, Jira, Azure DevOps) with validated Life Sciences platforms (e.g., Veeva, Medidata, SAP S/4HANA, LIMS/ELN).


• Define KPIs and lead development of dashboards (Power BI/Tableau) to provide executives with clear visibility into milestones, quality metrics, and transformation outcomes.

People Leadership & Cross-Border Delivery

• Manage and coach teams across regions, set goals, provide feedback, and ensure GxP awareness and audit-ready documentation.


• Lead distributed delivery with seamless US–India collaboration, ensuring consistency and accountability.

Quality & Risk Management

• Maintain EY quality and risk standards, ensuring validation traceability, ALCOA+ data integrity, and robust change control throughout delivery.

Skills

• Technical Proficiency: Strong understanding of the technology solutions being implemented, including software, hardware, and integration processes.


• Sector Specialist: Deep understanding of Life Sciences value chains, regulatory environment, and operating models.


• Leadership Presence: Strong leadership skills and the ability to work collaboratively in a team environment, demonstrate inclusivity, and embrace diverse perspectives.


• Sector Specialist: Deep understanding of Life Sciences value chains, regulatory environment, and operating models.


• Analytical Skills: Ability to break down complex problems and communicate insights through clear, structured narratives. Ability to analyze business processes and identify areas for improvement.


• Communication Skills: Strong verbal and written communication skills to interact with team members and clients, especially senior stakeholders.


• Problem Solving: Strong problem-solving skills to address challenges that arise during implementation. The ability to take the initiative, manage responsibilities, and deliver high-quality work across multiple workstreams.


• Interpersonal Skills: Ability to build relationships with clients and stakeholders to foster collaboration and trust.

Qualifications

• Education: Bachelor’s degree in Business, Computer Systems, Engineering, Economics, or Social/Organizational Science; a graduate degree is preferred.


• Experience (Overall): 9-12 years total relevant experience (or 7+ with a graduate degree) with 5+ years leading in one or more of the following areas:
  
  
  
  • Transformation / PMO / EPMO design, Target Operating Model,
  
  
  • Process Redesign, and Maturity Assessment,
  
  
  • Capability Roadmap, End-to-End Technology Implementation,
  
  
  • Change Management, Data & Automation Enablement.
  
  
  
  


• Consulting Background: At least 4+ years of external client-facing consulting experience, including managing client relationships at a large, multinational consulting firm


• Life Sciences Experience: Relevant experience with SPM Solutions implementation methods/plans/approaches and tools usage, TMVR for Business Case/Case for Change, Value Planning and Realization in the value chain (KPIs, Metrics), Complex Program (Risk, Readiness, Integrated Planning)


• People Leadership: Experience mentoring, developing talent, and managing direct reports.


• Tooling: Hands-on with Planview/Clarity (or equivalent SPM/PPM), Jira or Azure DevOps, and MS Project/Primavera; able to guide Power BI/Tableau and advanced Excel reporting.

What we look for

People who can develop and implement creative solutions to challenging problems and work well with teams to do it. We look for people with an entrepreneurial spirit: innovative by nature, always creating new approaches, products, services, and technologies. Helping clients solve tough problems and implement solutions requires strong intellectual abilities and rigor as well as a practical sense of what works and what does not. We seek people who strive to lead themselves, their teams, and their communities, and who can foster effective teamwork to drive results. Is this you?

What working at EY offers

At EY, we’re dedicated to helping our clients, from startups to Fortune 500 companies and the work we do with them is as varied as they are. You get to work on inspiring and meaningful projects. Our focus is education and coaching alongside practical experience to ensure your personal development. We value our employees, and you will be able to control your own development with an individual progression plan. You will quickly grow into a responsible role with challenging and stimulating assignments. Moreover, you will be part of an interdisciplinary environment that emphasizes high quality and knowledge exchange.

Plus, we offer:

• Support, coaching and feedback from some of the most engaging colleagues around


• Opportunities to develop new skills and progress your career


• Freedom and flexibility to handle your role in a way that’s right for you