Postdoctoral position on osteochondral tissue engineering for joint restoration

Postdoctoral position on osteochondral tissue engineering for joint restoration

100%

The Clinic of Orthopedics and Traumatology at the University Hospital Basel in Switzerland is currently seeking a postdoctoral fellow to work within the Cartilage Engineering and the Tissue Engineering groups at the Department of Biomedicine (DBM) in the area of joint tissue repair, focusing on engineering of osteochondral grafts. The Clinic of Orthopedics and Traumatology, directed by Prof. Andreas Müller, aims at implementing innovative regenerative cell-based therapies for the treatment of degenerative diseases in the joint. The Tissue Engineering group (directed by Prof. Ivan Martin) and the Cartilage Engineering group (directed by Prof. Andrea Barbero) are interdisciplinary teams with expertise in the biological and engineering sciences, as well as clinical trials with cell-based treatments for musculoskeletal tissue regeneration. The DBM is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel at 6 different locations. Be part of our future! Postdoctoral position on joint tissues repair (level of employment: 100%):

Your position

The project aims at developing new scientific approaches, with associated biological basis and clinical translation trajectory, for repair of osteochondral tissues.
The candidate is expected to:

• Design and test bioengineering concepts for the generation of osteochondral grafts in a clinically relevant size
• Investigate the postulated biological mode of action of the grafts
• Develop release criteria and validate the associated assays (viability, potency, identity, purity) according to cellbased medicinal product guidelines
• Support in developing regulatory documentation and manufacturing protocols
• Organize and conduct animal studies to generate pre-clinical data

Your profile

• A PhD in Biomedical Science or a closely related field
• Strong motivation and interest to work in basic and translational research
• Excellent communication skills and ability to work in interdisciplinary teams
• Experience in supervising students
• Excellent command in English, spoken and written
• High reliability, flexibility and problem-solving attitude
• Hands-on experience with cell culture techniques and biomaterials
• Prior experience in chondrocyte/bone cell biology or joint repair is an asset

We offer you

• An inspiring environment involving translation of basic scientific concepts into clinical applications
• Working in close interaction with interdisciplinary and internationally competitive teams
• Attractive working conditions and salary according to the standards of the University of Base

The project aims at developing new scientific approaches, with associated biological basis and clinical translation trajectory, for repair of osteochondral tissues.
The candidate is expected to:

• Design and test bioengineering concepts for the generation of osteochondral grafts in a clinically relevant size
• Investigate the postulated biological mode of action of the grafts
• Develop release criteria and validate the associated assays (viability, potency, identity, purity) according to cellbased medicinal product guidelines
• Support in developing regulatory documentation and manufacturing protocols
• Organize and conduct animal studies to generate pre-clinical data