Research Laboratory Technician Position in Diabetes/Immunometabolism Lab

University of Basel

| 80-100%, starting anytime <br><br>The research group Diabetes under guidance of Prof. Marc Donath offers a Research Laboratory Technician position in the context of endocrinology/metabolism/diabetes. This position will be based in the Department of Biomedicine ( https://biomedizin.unibas.ch ) at the University of Basel/University Hospital Basel, Switzerland. <br><br>The Diabetes group studies the pathogenesis of type 2 diabetes and in particular how components of the immune system interact with endocrine pathways to manage energy distribution and tissue metabolism. We focus on hormones secreted by pancreatic islet cells, tissue macrophages and the pathological/physiological role of the macrophage-derived cytokine Interleukin-1 beta. <br><br><b>Your position</b> <br><br>Support PhD candidates in their projects with hands-on work. Develop and run assays. Manage data. Help to run the lab by performing common lab task such as ordering and re-stocking materials. Show interest in, discuss and provide input to various research projects. <br><br><b>Your profile</b> <br><br>The candidate is expected to be have a Laboratory technician apprenticeship or a Bachlor's Degree, be enthusiastic about immune-metabolic research and interact and exchange with other members of the lab. The candidate should be comfortable working with mice and prior experience with in vivo work are of advantage. The primary lab language is English and good written and oral skills are required. <br><br><b>We offer you</b> <br><br>Position in an international and competitive environment where basic and clinical research meet. The applied research models are predominantly genetically-modified in vivo and ex vivo mouse models in combination with pharmacological tools. Other state-of-the-art lab techniques applied are flow-cytometry, histology, qPCR as well as various protein and enzyme activity assays. <br><br><b>Recent relevant publications:</b> <br><br>Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing. Meier et al. Nat Comm 2022. PMID: 35963866 <br><br>The cephalic phase of insulin release is modulated by IL-1l. Wiedemann et al. Cell Metab 2022. PMID: 35750050 <br><br>Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1l. Hepprich et al. Cell Metab 2020. PMID: 32197070 <br><br>Postprandial macrophage-derived IL-1l stimulates insulin, and both synergistically promote glucose disposal and inflammation. Dror et al. Nat Immunol 2017. PMID: 28092375 <br><br><b>Application / Contact</b> <br><br>Please include a CV and a motivation letter in your initial inquiry. <br>Daniel Zeman-Meier, daniel.zeman [at] unibas.ch <br><br>www.unibas.ch - Health - Santé - Gesundheit - Life Sciences - Sciences de la vie - Biowissenschaften - Reference: jobs.myscience.ch/id63994

North West Switzerland, Switzerland