PhD student position: deciphering the molecular basis of allostery in CRISPR associated proteins usi

We are on the lookout for a creative PhD student position: deciphering the molecular basis of allostery in CRISPR associated proteins using single-molecule experiments to join our growing team at The Biozentrum, University Of Basel in Basel Basel-City
Growing your career as a Full Time PhD student position: deciphering the molecular basis of allostery in CRISPR associated proteins using single-molecule experiments is an amazing opportunity to develop exceptional skills.
If you are strong in creativity, project management and have the right personality for the job, then apply for the position of PhD student position: deciphering the molecular basis of allostery in CRISPR associated proteins using single-molecule experiments at The Biozentrum, University Of Basel today!

Your position This PhD project will grow with you. You will create time-resolved direct observations of single CARF proteins – aka. CRISPR suicide proteins – undergoing allosteric activation, substrate processing, deactivation, etc. How this works, on what timescales, by which conformational rearrangements has not been observed yet in real-time, leaving the underlying molecular processes obscure. In this PhD project, you'll be able to solve (some of) these nanoscale puzzles. Steps involved in the project:Single-molecule fluorescence/FRET/DyeCycling experimentsSolid-state nanopore/NEOtrap experimentsAdvanced data analysis, coding, kinetic modelingProtein production and functionalization Your profile Prior experience in several of these areas is desired:Single-molecule experiments and interpretationAdvanced data analysis, coding, modeling, machine learningOptics and fluorescence microscopy and/or nanopore techniquesProtein biochemistryEssential requirements:MSc degree in physics or (bio-)chemistry with excellent gradesHigh motivation and curiosity about fundamental questions on the physical-chemistry of lifeIndependent analytical thinking and systematic work styleExcellent experimental problem-solving skills and perseveranceFriendly team player proficient in English communication (speaking & writing)

Benefits of working as a PhD student position: deciphering the molecular basis of allostery in CRISPR associated proteins using single-molecule experiments in Basel Basel-City:

● Excellent benefits
● Company offers career progression opportunities
● Attractive package