Associate Scientist / Research Scientist Upstream Process Sciences

About the Role

To strengthen our Drug Substance Process Sciences team, we are seeking a
talented and motivated Associate Scientist / Research Scientist to
support upstream process development for biologics.

You will contribute to early-stage process development, process
optimisation, technology transfer, and manufacturing support activities.
Working within a multidisciplinary team, you will help develop scalable
mammalian cell culture processes, perform process characterisation and
troubleshooting studies, and support the delivery of innovative protein
therapeutics.

This is a laboratory-based role offering exposure to advanced cell
culture technologies, high-throughput platforms, and bioreactor systems ranging
from microscale to pilot scale.

Your Activities

Process Development & Laboratory Operations

· Design, plan, and execute upstream process
development studies with minimal supervision.

· Apply QbD and DoE approaches to process
optimisation and characterisation.

· Perform mammalian cell culture experiments using
shake flasks, Ambr® systems, and laboratory-scale bioreactors.

· Support scale-up, scalability assessments, process
troubleshooting, and technology transfer activities.

· Utilise automation and high-throughput technologies
to improve workflow efficiency.

· Contribute to evaluation of emerging technologies
and platform improvements.

Data Analysis & Scientific Communication

· Analyse and interpret experimental data using
appropriate statistical approaches.

· Generate accurate, high-quality scientific data and
documentation.

· Prepare technical reports, protocols,
presentations, and project summaries.

· Communicate findings and recommendations to project
teams and stakeholders.

Collaboration & Compliance

· Collaborate with Cell Line Development, Analytical
Sciences, Downstream Development, Manufacturing and external partners.

· Represent Upstream Process Sciences in
cross-functional project teams.

· Maintain accurate laboratory records and electronic
laboratory notebooks.

· Ensure compliance with HSE, GMP/GSP, quality
systems, and data integrity requirements.

· Participate in continuous improvement initiatives
and laboratory best practices.

Requirements

Technical Skills & Experience

· Experience in mammalian cell culture and biologics
process development.

· Hands-on experience with CHO cell culture and
therapeutic protein production.

· Experience operating Ambr® and/or laboratory-scale
bioreactor systems.

· Knowledge of cell culture scale-up principles and
process characterisation.

· Experience applying DoE and statistical data
analysis tools.

· Strong scientific problem-solving and
troubleshooting skills.

· Experience with automation, digital tools, and data
management systems.

· Understanding of GMP, data integrity, and quality
requirements.

Advantageous

· Perfusion or ATF process experience.

· Technology transfer and manufacturing support
experience.

· Exposure to downstream processing and integrated
process development.