Clinical Trial Manager

Job Description

Clinical Trial Manager

Our Destination – ‘Relentless Medicine Discovery’

We don’t know enough about human biology. The way medicines are discovered is too slow. Discovering something new requires something different. People deserve better medicines faster.

What’s needed? Relentless creativity. Relentless technology. Relentless collaboration. Relentless medicine discovery.

What’s needed is Tangram Therapeutics.

We are committed to uniting computation, RNAi, and unconventional thinking to make better medicines faster. Leveraging our LLibra OS AI platform and GalOmic RNAi chemistry platform, we identify novel gene targets and develop differentiated GalNAc-siRNA therapies that will make a meaningful difference to patients. It’s discovery primed for real-world drug development.

Our Journey – ‘Expediting exploration through unconventional thinking’

Tangram is made up of relentless explorers. People that thrive in a culture of innovation. Collaborators who make sense of complex patterns. Humans that actually care about expediting the discovery of promising drugs. To drive real change in our lifetime.

In joining us, you’ll be part of a team that refuses to accept limits. We move fast, think differently, and work together to uncover the breakthroughs that matter most. Here, curiosity is encouraged, ideas are valued, and your work will help shape the future of biotech in ways that make a tangible difference.

Your Adventure

This position offers an amazing opportunity to build sponsor oversight capabilities in a pioneering RNAi/oligonucleotide platform biotech. You will lead the planning, execution, and oversight of early clinical development programmes, combining strategic vision with hands-on involvement. Working closely with CROs, investigators, and internal teams, you will ensure the successful delivery of high-quality clinical trials in a lean and agile environment.

Reporting into Senior Director, Head of Clinical Operations.

Based in our office in Paddington, London, UK. The working hours for this role are 35 hours per week, Monday to Friday.  Current hybrid working arrangements permit Friday working from home.

What you will do:

• Lead the planning, start-up, and execution of clinical trials, ensuring delivery to time, quality, and budget


• Act as the primary sponsor contact for CROs, investigators, and providers, driving performance and accountability


• Oversee CRO performance: review monitoring reports & KPIs, assess data quality and compliance, and conduct co-monitoring visits as required.


• Partner with Regulatory Affairs on ethics/regulatory submissions; ensure compliance with ICH-GCP and applicable UK/EU regulations, staying current with forthcoming UK clinical trials regulations


• Maintain trial inspection readiness, overseeing documentation, safety reporting, vendor governance and audit response


• Support development of protocols, informed consent forms, case report forms, and study reports ensuring operational feasibility and data integrity


• Drive risk management, issue resolution, and cross-functional collaboration in a lean, agile environment


• Contribute to shaping and improving Tangram's Clinical Operations processes and SOPs as we build capabilities

Skills & Qualifications

Essential:

• Bachelor’s degree (or equivalent experience) in a life science or health-related discipline.


• 8+ years of experience in clinical trial management within pharmaceutical, biotech, or CRO settings, ideally with early development exposure


• Prior site monitoring experience or demonstrable ability to critically assess CRO monitoring performance


• Strong knowledge of ICH-GCP and global regulatory requirements, with awareness of evolving UK/EU regulations (including UK CTR 2026)


• Proven expertise in CRO and vendor governance, including financial oversight


• Ability to manage complex timelines and competing priorities in a lean, agile biotech environment


• Strategic yet hands-on, comfortable moving between high-level planning and detailed site/vendor oversight


• Strong communicator with the ability to manage internal and external stakeholders with accountability and transparency


• Comfortable operating in an evolving environment, applying judgement to balance strategic and operational needs

Nice to have:

• Familiarity with common clinical systems (e.g. eTMF, EDC, safety databases)


• Experience with RNAi, oligonucleotides, or rare/metabolic disease programmes


• Contribution to SOP development or process building in a biotech setting

Our Cultural Code

Tangram’s set of core values form a relentless PACT – our people use it as a promise to each other, investors, partners and the wider world.  It helps us unite computation, RNAi and unconventional thinking.  All with the aim to make medicines faster.

• Passion to do better


• Adaptability to find the answer


• Curiosity at every step


• Tenacity to do things differently

Our Benefits

We support our people in the UK and US to develop as healthy, ambitious human beings.

Committed to Care

Healthcare, pension/401(k) & life assurance

Celebrating Success

Performance related bonus, competitive salary & PACT Awards

Unlocking Potential

Personal development time, departmental learning and development budget.

Enjoying Life

Social and wellbeing activities, competitive holiday/PTO policy.

Diversity, Equality & Inclusion

Our ambition is to have a positive impact on society at a global level by discovering and developing therapeutic targets in areas of high unmet need.

We believe that providing equal opportunities, valuing diversity, and promoting a culture of openness and inclusivity are vital in the journey to realise our ambition. Our aim is to create an environment where people are free to be themselves regardless of their identity or background.