Principal Scientist- Clinical Pharmacology

PRINCIPAL SCIENTIST - CLINICAL PHARMACOLOGY 

Unity Campus - Cambridge

About Maxion

Maxion Therapeutics is a biotechnology company developing antibody-based drugs for previously untreatable ion channel- and G protein-coupled receptor (GPCR)-driven diseases, including autoimmune conditions, chronic pain, and cardiovascular disease.

The Company is developing a pipeline of potentially first- and best-in-class therapeutics using its proprietary KnotBody technology to generate potent, selective, and long-acting therapeutics by combining naturally occurring mini-proteins (‘knottins’) with antibodies using state-of-the-art phage and mammalian display technologies.

Maxion was founded in 2020 by highly respected biotech entrepreneurs and scientists Dr John McCafferty, CTO and Dr Aneesh Karatt-Vellatt, CSO. Dr McCafferty previously co-invented antibody phage display, which was the subject of the 2018 Nobel Prize in Chemistry awarded to his co-inventor Sir Gregory Winter.  Maxion’s portfolio and growth is being advanced by a team of highly experienced leaders in the discovery and development of antibody-based drugs. The Company is based near Cambridge, UK and is backed by international blue-chip investors. For more information, please visit:

https://www.maxiontherapeutics.com/.           

About the Role

We are seeking a highly organised and proactive Clinical Pharmacologist to oversee and manage all clinical pharmacology activities for our lead programme, MAX001, currently in IND-enabling development. Reporting directly to the Chief Development Officer (CDO), the successful candidate will assume full responsibility for managing and coordinating all Pharmacokinetic, Immunogenicity and Bioanalytical studies.

The ideal candidate will have a strong background in non-clinical and early clinical development of biologics, excellent communication skills, and a collaborative approach to working with internal and external stake holders.

Key responsibilities

• Manage all Clinical Pharmacology aspects for MAX001 during pre-clinical and clinical development


• Implement project specific Clinical Pharmacology strategies and present these to internal teams


• Interact with internal bioanalytical team members as well as CROs for the development, transfer and validation of PK,


•  immunogenicity and selected pharmacodynamic assays


• Closely interact with other functions within the Research and Development area to optimize non-clinical and clinical development concepts


• Coordinate and prepare Clinical Pharmacology related sections in all submission relevant documents such as IB, study protocols, study reports, IND dossier documents as well as publications

Candidate Profile

• Degree in Life Sciences, Chemistry, Pharmaceutical Sciences or equivalent relevant experience.


• Strong Pharmaceutical industry experience preferentially with a background in the development of new biologic entities (NBEs)


• Expertise in Clinical Pharmacology comprising PK, PK/PD, immunogenicity and ideally DER data analysis and application of model-informed drug development


• Strong project management, organisational, and communication skills.


• Ability to effectively manage priorities, problem-solve proactively, and adapt to rapidly evolving project demands.


• Actively contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams.


• Desire and ability to work in a fast-paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals with a can-do attitude.

What can we offer you?

• A competitive salary


• A comprehensive benefits package including generous pension contribution, Private Life and Medical Insurance, Cycle to Work Scheme, participation in the company Share Option Scheme, and more.


• Significant opportunities for career progression within a dynamic company. 


• Located in a state-of-the art Science Park with easy access to Cambridge by car, train and bus, and offering on-site gym, cafe, and a vibrant social community.


• Working alongside an innovative team of scientists, including the founders, who are Key Opinion Leaders in the field.


• A supportive work environment with a key focus on fostering collaborative working environment within a friendly team.

This is a permanent position.

Agencies: We are recruiting this role directly with our in-house talent team, so do not need support from agencies.  We also have our own preferred suppliers list which is not being reviewed for additions in the next 12 months.