Principal Scientist - Enzymology

Principal Scientist - Enzymology

Cambridge

Permanent

SRG are currently supporting the search for a Principal Scientist with an expertise in enzymology.

You will be an inspirational scientist with an exceptional record of bringing your deep knowledge of enzymology and biochemistry to impact on projects. Within this role you will be brining scientific leadership to the design of biochemical assays and bespoke mechanistic data helping to characterise cancer targets.

The successful candidate will have a recent background in the mechanistic study of enzymes, assay development, and leadership experience within the drug discovery field (compound handling, mechanism of inhibition studies). You will need to demonstrate leadership capabilities, driving innovation and strategic decision making.

The Role:

• Provide scientific leadership to define and implement best practice for biochemical assays and bespoke mechanism of action studies.
• Design and develop novel physiologically relevant biochemical assays for a range of target classes, using recombinant proteins
• Characterise cancer targets in detail at the molecular level
• Define biochemical profiling cascade to support characterisation of novel small molecules for oncology targets
• Characterise small molecules in vitro using recombinant proteins and a range of biochemical assay technologies, with a particular focus on detailed kinetic and mechanism of inhibition studies and their translation into the cellular environment.
• Represent the department across a broad range of projects and cross-site initiatives, both internally and externally.
• Prioritise own work and that of line reports according to project goals and take responsibility for the timely delivery of team objectives
• Manage performance and development of line reports

Requirements:

• PhD (or equivalent) in Enzymology, Pharmacology, or equivalent experience
• Significant experience and deep expertise in enzymology in a drug discovery environment - Critical
• Detailed understanding of steady-state and pre-steady-state enzymology. A strong background in Mechanistic Enzymology is essential.
• Detailed theoretical and practical understanding of biochemical assays and detection technologies, with a particular focus on physiologically relevant systems
• Significant experience of assay development for a range of target classes
• Strong external reputation in enzymology, evidenced through wide personal network, external presentation and publication, and presentation at key conferences.
• Key techniques to highlight on your CV - Biochemical Assay Development - Recombinant Protein Based Assays - Assay Readouts: Fluorescence, luminescence, HTRF, Fluorescence polarisation

Apply now by attaching your CV in Word, or contact Selby De Klerk for further information about this new role: +

Interested? Or know someone who will be?
SRG are the UK number 1 recruitment company specialising in the science, engineering, clinical, pharmaceutical, food/FMCG, renewable, biotech, chemicals and medical devices sectors. As scientists ourselves, our specialist sector knowledge and our passion are worlds class. It's this combination that makes us different.

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.