Principal Scientist I (LCMS/MS)

Job Purpose

The Principal Scientist I (Mass Spectrometry) aids in driving strategic scientific growth within our mass spectrometry group by leading high-impact value‑creation initiatives, mentoring junior staff, and expanding in-house capabilities. You will support business development through scientific proposal writing, client interactions, and by serving as a subject-matter expert on advanced bioanalytical assays with predominantly LC‑MS endpoints. Your leadership will champion scientific excellence, reinforce GxP compliance, and elevate our CRO’s reputation via publications, workshops, and cross-functional collaborations.

Main Areas of Responsibility

• Business Development & Scientific Strategy
  
  
  
  • Collaborate with BD teams to develop scientific content for proposals, drive technical discussions with clients, and cultivate long-term relationships.
  
  
  • Identify emerging industry needs and overseeing Value Creation Projects (VCPs) and advancing in-house capabilities to expand our assay portfolio.
  
  
  
  


• Assay SME & Method Innovation
  
  
  
  • Lead feasibility studies and perform/oversee method development for the complex bioanalytical assays requested by our clients (including small molecules, large molecules, and new modalities at all stages of the development cycle).
  
  
  • Lead transfer of the methods to study delivery group for validation and sample analysis, and monitoring study progress as the methods are employed.
  
  
  • Serve as the SME for complex bioanalytical assays (scientific rationale, sample preparation, chromatography, mass spectrometry, hybrid applications, trouble-shooting etc).
  
  
  
  


• Leadership & Mentoring
  
  
  
  • Mentor and train junior and mid-level scientists on advanced assay design, troubleshooting, data analysis, regulatory requirements and GxP documentation.
  
  
  • Delegate responsibilities and review deliverables to ensure scientific rigor, data integrity, and on-time delivery.
  
  
  
  


• Scientific Excellence & External Engagement
  
  
  
  • Drive continuous improvement through internal audits, protocol enhancements, and corrective-preventive action initiatives.
  
  
  • Represent the company at scientific conferences, workshops, and in peer-reviewed publications to showcase our capabilities and thought leadership.
  
  
  
  

Qualifications & Experience

• PhD in Chemistry, Biochemistry, Biology or related discipline with ≥2 years’ industry experience OR MSc/BSc in a relevant field with ≥7 years’ hands-on experience.


• Deep expertise in regulated bioanalytical environments (GLP/GCP) and familiarity with ICH bioanalytical guidelines.


• Demonstrated track record leading/performing development of bioanalytical LC‑MS assays for PK and/or PD applications in biological fluids and tissues using triple quadrupole instruments.


• Excellent leadership, project management, and cross-functional collaboration skills.


• Proven experience in business-facing roles: proposal writing, client presentations, and technical negotiations.


• Strong written and verbal communication skills in English.

Preferred Skills & Experience

• Experience in the bioanalytical quantitation of large molecules and new modalities using LC-MS


• History of leading or co-authoring peer-reviewed publications or patents in bioanalysis.


• Performed role of Study Director/ Principal Investigator/ Responsible Scientist in the support of regulatory studies.


• Bioanalytical CRO experience.


• Experienced user of high-resolution mass spectrometers.


• Experience of interactions with health authorities (FDA, EMA, MHRA).

PLEASE ENSURE THAT YOUR CV/RESUME IS SUBMITTED IN ENGLISH.