Principal Scientist LC-MS/MS Bioanalysis (PK/PD, Complex Modalities)

Role Overview

We are seeking a Principal Scientist to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.

Key Responsibilities

• Provide scientific leadership and SME support across LC-MS/MS studies


• Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness


• Advise on method development, optimisation, and validation strategies


• Support study teams in resolving technical issues and ensuring consistent assay performance


• Contribute to client interactions, including scientific discussions, data interpretation, and method justification


• Support proposals, bid defences, and scientific strategy discussions


• Mentor and support development of laboratory scientists

Technical Expertise

• Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems


• Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows


• Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects

Experience with Complex Modalities

• Peptides and proteins


• Oligonucleotides


• Antibody-drug conjugates and related conjugates

Regulatory and Client Experience

• Extensive experience working under GLP and GCP


• Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)


• Experience supporting audits and regulatory inspections


• Proven ability to lead scientific discussions with clients and defend analytical approaches and data


• Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate

Qualifications and Experience

• PhD in Analytical Chemistry or related field, or MSc with significant industry experience


• 10 to 15 or more years of LC-MS/MS bioanalysis experience


• Demonstrated expertise in method development, validation, and advanced troubleshooting