Protein Scientist

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Piramal Pharma Solutions is a contract development and manufacturing  organization (CDMO), offering end-to-end development and manufacturing  solutions across the drug life cycle. We serve our clients through a globally integrated network of facilities in North America, Europe and Asia.  

This enables us to offer a comprehensive range of services including Drug Discovery  Solutions, Process & Pharmaceutical Development services, Clinical Trial  Supplies, Commercial supply of APIs and Finished dosage forms. We also offer  specialized services like development and manufacture of Highly Potent APIs  and Antibody Drug Conjugation.  

Our capability as an integrated service provider  & experience with various technologies enables us to serve Innovator and  Generic companies worldwide.  

For more details, please visit : www.piramalpharmasolutions.com

Job Title

Job Description

Job Summary
We are seeking a highly motivated and skilled Protein Scientist to join our research and development team. The successful candidate will be responsible for the expression, purification, and characterization of various proteins to support drug discovery and development projects within Piramal Healthcare UK Limited.

Job Responsibilities
* Design and execute experiments for the expression of recombinant proteins in various host systems (e.g., bacterial, insect, mammalian cells).
* Develop and optimize protein purification strategies using a range of chromatographic techniques (e.g., affinity, ion exchange, size exclusion).
* Perform biophysical and biochemical characterization of purified proteins to assess purity, integrity, activity, and stability (e.g., SDS-PAGE, Western blot, mass spectrometry, DLS, SEC-MALS, thermal denaturation assays).
* Contribute to the design and execution of protein engineering experiments to improve protein properties or function.
* Maintain detailed and accurate records of experimental procedures, results, and data analysis.
* Interpret experimental data, troubleshoot technical issues, and present findings to internal teams.
* Collaborate effectively with colleagues across different disciplines, including molecular biology, assay development, and structural biology.
* Stay current with scientific literature and new technologies in the field of protein science.
* Adhere to all safety regulations and good laboratory practices.

Job Qualifications
* Ph.D. in Biochemistry, Molecular Biology, Protein Science, or a related field with 0-3 years of relevant industry experience, or an M.S. with 3-5 years of relevant industry experience.
* Proven expertise in protein expression systems (e.g., E. coli, baculovirus/insect cells, mammalian cells).
* Extensive hands-on experience with various protein purification techniques (e.g., ÄKTA FPLC systems, affinity chromatography, IEX, SEC).
* Proficient in a range of protein characterization methods (e.g., SDS-PAGE, Western blot, mass spectrometry, DLS, fluorescence spectroscopy).
* Strong understanding of protein structure-function relationships.
* Excellent problem-solving skills and the ability to work independently as well as part of a team.
* Strong written and verbal communication skills.
* Ability to manage multiple projects simultaneously and meet deadlines.
* Experience with protein engineering techniques is a plus.
* Familiarity with pharmaceutical drug discovery and development processes is desirable.