Senior Bioinformatician - In-silico Protein Design

Senior Bioinformatician – In-silico protein design 

T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics. We are seeking a highly motivated Senior Bioinformatician with a strong background in protein engineering to advance our biologics platform as part of the Computational Biology team.  

What you will do 

This role will involve driving bioinformatics and ML-based efforts to engineer bispecific immune cell engagers towards our clinical programmes. The ideal candidate would have a strong background and interest in applying computational methods towards protein engineering, ideally including developability assessment. The role will involve exploratory bioinformatics, deploying ML-based approaches, and developing pipelines to expand on and enhance our analysis & data infrastructure.  

Key Responsibilities 

• Drive innovation in the application of computational techniques to protein engineering of clinical molecules  

• Guide data generation to support development of new computational techniques and ML models  

• Train and deploy ML approaches for improving protein engineering processes  

• Develop and deploy tools and metrics for assessment of molecule developability  

• Develop and integrate bioinformatics pipelines with our analysis & data infrastructure 

• Regularly communicate findings and developments with the Research team and management 

• Participate in group and project meetings, offering insights and expertise on technical elements to advance research projects 

• Maintain and implement good code, version control, and organisation of data 

To be successful you will need 

• Appropriate qualifications / experience in bioinformatics, one of:
  
  
  
  • Relevant BSc with 3+ years relevant industry experience
  
  
  • Relevant MSc with 2+ years relevant industry experience 
  
  
  • Relevant PhD 
  
  
  
  

• Demonstrated experience and strong interest in utilising computational techniques within protein engineering  

• Experience with at least applying ML techniques to protein engineering, ideally developing and training ML models in the area  

• Strong Python skills and knowledge of general software development techniques and standards  

• Ideally, some experience of developability assessment in drug development  

• Passionate about bioinformatics, coding, and the biological applications of computational techniques 

• Desire to develop clinical TCR-based therapeutic molecules 

• Ability to adapt to multiple roles in an evolving company 

• Enjoy working towards challenging goals in a fast-moving environment 

• Strong organizational and communication skills (both written and verbal) 

• Strong drive to deliver on company milestones and goals 

What we offer 

Competitive salary and benefits commensurate with qualifications and experience. 

Modern, well-equipped office and laboratory facilities on Oxford Science Park. 

Training and development opportunities in-line with the company’s goals and growth plans. 

An exciting opportunity to help establish an early-stage biotech with ambitions to impact patients’ lives. 

How to apply 

Applications will be evaluated in the order that they are received, you are encouraged to apply as soon as possible. 

Applications will close once the position is filled.