Senior / Principal Scientist

Help drive the TCR engineering processes and development by leading in vivo and in vitro validation of TCEs. You'll get involved in purifying recombinant TCRs to perform high-throughput TCR display methods and deep sequencing.

Client Details

The client are reimagining what's possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target solid tumours-diseases long considered out of reach for conventional immunotherapies.

Description

• Lead in vivo and in vitro validation of TCEs.
• Collaboratively design and characterise TCRs for proprietary and partnered disease targets.
• Conduct a suite of protein science operations, including expression, purification, and biophysical analysis.
• Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing.
• Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation.
• Join forces with founders, R&D, academia, and industrial stakeholders to fulfil ambitious R&D objectives.
• Draft, revise, and oversee repertoire of lab protocols.
• Offer essential lab support and uphold facility upkeep

Profile

• PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required.
• For senior scientist we are looking for over 3 years industry experience.
• Experience in in vivo and in vitro validation of TCEs (T-cell engagers) all the way though to investigational new drug (IND) approval is critical Knowledge of molecular biology protocols, with an emphasis on cloning and PCR is preferred.
• A background in protein expression, purification and biophysical characterisation is preferred.
• Experience in cell and immunological assays (flow cytometry, ELISA etc.) is desired.
• Experience in NGS analysis pipeline (specifically data analysis using software such as R) is desired.
• SOP documentation experience is desired.

Job Offer

• Market-competitive salary and stock option package.
• A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday!
• Access to fully equipped private lab.
• Flexibility to work from home as project demands allow.
• A supportive, cross-disciplinary team fostering a highly collaborative work environment.