Research Associate, Protein Sciences (Temporary 4-6 months)

Manifold Bio is a dynamic biotech company building a pipeline of  targeted biologics using a novel in vivo-centric discovery approach. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.

Position

We are seeking a highly motivated and enthusiastic individual to be an integral part of our protein science team. This person will be responsible for expressing, purifying, and characterizing novel multispecific antibody drug formats for in vitro and in vivo experiments.. They will work closely with a collaborative team of scientists to design, execute, and analyze experiments in a fast-paced environment.

Responsibilities

• Maintain mammalian cell cultures and perform transient transfections to produce protein therapeutic candidates


• Purify antibodies and other proteins using AKTA FPLC systems 


• Characterize proteins using techniques such as SDS-PAGE, HPLC-SEC, DLS, and UV-Vis spectrophotometry


• Purify and prepare plasmid DNA for transfections


• Organize and maintain protein inventories


• Plan and perform experiments, analyze data, and present results in group meetings


• Document experiments in an electronic lab notebook

Required Qualifications

• BSc and a minimum of 6 months of industry experience


• Hands on experience with mammalian cell culture


• Experience purifying proteins on AKTA FPLC systems


• Hard-working, scientifically curious, and enthusiastic to contribute to cutting-edge work


• Strong verbal and written communication skills


• Detail-oriented and able to multitask


• Able to work well as part of a team

Preferred Qualifications

• Proficient with basic protein characterization methods such as SDS-PAGE, HPLC, UV-Vis


• Experience with transient transfections in HEK293 or CHO cells


• Molecular biology skills such as DNA preparation

This Role Might Be Perfect For You If

You are curious and passionate about science and drug discovery and want to work with a fast-moving team that values scientific boldness and innovation. This role requires deep technical expertise combined with a willingness to work thoughtfully and quickly to solve scientific challenges in a collaborative manner. You should be a team player who is also proactive and resourceful.

If you’re excited to use unique protein technologies to shape an innovative drug development strategy, build meaningful industry partnerships, and contribute directly to our mission of advancing breakthrough treatments, please apply!

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.