Senior Associate Scientist / Principal Associate Scientist, Translational Research, Contractor

Generation Bio is a biotechnology company changing what is possible for people living with T cell-driven autoimmune diseases. The company is developing novel therapeutics leveraging its T cell selective cell-targeted lipid nanoparticle (ctLNP) to deliver siRNA in vivo, enabling modulation of T cell activity that causes inflammation and auto-reactive tissue destruction. By selectively modulating T cells that drive disease pathology, ctLNP-siRNA therapeutics could potently block target function with sequence-level specificity while sparing the broader immune system. This potent new modality is designed to reach targets that are poorly drugged by other approaches, opening a broad indication space of T cell driven autoimmune diseases.

We are a thriving, collaborative, creative community of 100 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.  

Delve further.  Please visit www.generationbio.com or follow @generationbio. To see additional roles, please also check out https://generationbio.com/careers/ 

SUMMARY:

Generation Bio is seeking an energetic and highly motivated Senior Associate Scientist/Principal Associate Scientist contract role to join the Preclinical group. The position will independently drive biological assay development at the intersection of ex vivo and in vitro.  The ideal candidate will have a strong background in ex vivo cell isolation, qPCR, flow cytometry and related techniques.

Responsibilities:

• Develop quantitative nucleic acid assays to monitor target gene expression from in vitro and ex vivo samples


• Design experiments, analyze data and interpret results


• Present findings in group meetings and written reports


• Maintain accurate and up to date laboratory records


• Demonstrate positive attitude and commitment to overcoming obstacles to achieve project goals

Qualifications:

• BS. or M.S. with a minimum of 4 years industry experience.


• Experience isolating and culturing primary immune cells, such as T & B cells from blood or tissue


• Track record of developing quantitative RNA assays such as RTqPCR, Primeflow, QuantiGene or similar


• Experience with flow cytometry highly desired


• Experience with running western blots a plus


• Ability to work and troubleshoot independently

POSITION: Contract (6 months) 

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. 

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.