Advanced Practice Provider

The START Center for Cancer Research (“START”) is the world’s largest early phase site network, fully dedicated to oncology clinical research. Throughout our history, START has provided hope to cancer patients in global community practices by offering "Hope Through Access” to cutting edge trials throughout the United States and Europe.   

We are seeking an Advanced Practice Provider. The Advanced Practice Provider (APP) – Early Phase Clinical Research Program supports protocol-compliant patient care and clinical trial execution for Phase I and other early-phase oncology studies. Functioning as a sub-investigator under the supervision of the Principal Investigator (PI), the APP extends clinical capacity, supports screening and study visits, and enhances care coordination while preserving core investigator responsibilities specific to early-phase research

Work Schedule:  Monday-Friday 8:00am-5:00pm 

Location:  450 Lakeville Road, Entrance A, Lake Success, New York

The annual base salary for this role is $190K-$205K. However, base pay may vary depending on multiple individualized factors including market location, job-related knowledge, skills, and experience. 

Essential Responsibilities:

• Serve as a sub-investigator on assigned early-phase clinical trials following completion of required training and delegation documentation.


• Conduct protocol-required physical examinations and study visits for patients in screening, on treatment, and in follow-up as delegated by the Principal Investigator.


• Prepare comprehensive medical histories and clinical summaries in advance of new patient consults to support efficient PI evaluation.


• Assist with screening activities prior to new patient visits, including preliminary chart review and protocol feasibility assessment.


• Support post-consent screening by assisting with protocol-specific screening questions and required clarifications.


• Assist with the identification, documentation, and follow-up of adverse events (AEs) and serious adverse events (SAEs) in collaboration with the Principal Investigator and research team. Attend sponsor or safety calls designated as low priority or routine, as delegated by the Principal Investigator.


• Act as the first point of clinical contact for the research care team for day-to-day patient management questions and escalate issues to the Principal Investigator as appropriate.


• Coordinate with nursing, pharmacy, clinical research coordinators, and data management to ensure safe, efficient, and protocol-adherent care delivery.

Required Education and Experience:

• Advanced practice degree (Nurse Practitioner or Physician Assistant) with current licensure in the applicable state(s).


• Minimum of 5 years of experience in oncology clinical care or oncology clinical research.

Preferred Education and Experience:

• Master’s degree or Doctoral degree in advanced practice nursing or physician assistant studies.


• National certification as a Nurse Practitioner or Physician Assistant. Eligibility and willingness to serve as a sub-investigator on oncology clinical trials.


• Prior experience in early-phase (Phase I) oncology clinical research.

Physical & Travel Requirements:

• Travel: Limited travel may be required during training and onboarding.

Best-in-Class Benefits and Perks  

We value the time, talent, and dedication our employees bring to START. Our commitment to your well-being and growth is reflected in a competitive compensation package—based on experience—along with comprehensive benefits designed to support you both personally and professionally:  

• 401(k) retirement savings plan with employer match  

• Eligibility for an annual performance bonus, based on role and company results  

• Generous paid time off and paid holidays  

• Comprehensive medical, dental, and vision coverage and optional insurance options  

• Company  p‑aid life and disability insurance for added financial protection  

• Employee Assistance Program (EAP) providing confidential, no ‑cost support for you and your family from day one  

• Flexible FSA and HSA plans to support your financial wellness  

• Commitment to a supportive environment that values balance, wellbeing, and flexibility  

• We’re committed to fostering a collaborative, creative workplace where every team member is encouraged to contribute. At START, you’ll join a team that values continuous learning, professional growth, shared ideas, and a culture built on inclusivity and innovation.  

More About START  

START clinical trial sites have conducted more than 1,000 early-phase clinical trials, including dozens of therapies that were approved by the FDA or EMA. START represents the world’s largest roster of early-phase principal investigators across its Network of clinical trial sites. Committed to accelerating passage from trials to treatments, START delivers hope to patients, families, and physicians around the world via our mission of “Hope Through Access”. As an example, in San Antonio, where START was founded, START treated the first patient ever with Keytruda – one of the most effective cancer drugs in medical history.  

Learn more at STARTresearch.com.   

Ready to be part of a team changing the future of cancer treatment?  

Join us in our mission to conquer cancer, one clinical trial at a time. Your expertise and dedication can help us bring hope and healing to patients worldwide. Please submit your application online.  

We are an equal opportunity employer that welcomes and encourages diversity in the workplace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.