Associate Director, Medicinal Chemistry

Scientific Contribution: Design and execute synthetic routes for novel small molecules with desired pharmacological profiles, ADME properties, and physicochemical characteristics in the context of oligo delivery. Critically analyze SAR (Structure-Activity Relationships) and SPR (Structure-Property Relationships) data to guide compound design and optimization efforts. Drive the strategic direction of medicinal chemistry efforts within projects, ensuring alignment with program goals and timelines. Stay abreast of current literature, emerging technologies, and competitive landscape in medicinal chemistry and drug discovery. Contribute to the identification of new drug targets and therapeutic hypotheses. Collaborate closely with computational chemists to leverage advanced modeling techniques for compound design and lead optimization. Provide scientific guidance and mentorship to more junior chemists, fostering a culture of scientific rigor and continuous learning. Contribute to the generation and defense of intellectual property (e.g., patent applications, scientific publications). Ph.D. in Organic Chemistry. Greater than 8 years of progressively responsible experience in small molecule drug discovery within a pharmaceutical setting. Demonstrated experience in advancing at least one compound into clinical development as a group leader or key contributor. Strong theoretical and practical knowledge of modern synthetic organic chemistry, reaction mechanisms, and retrosynthetic analysis. Extensive experience in small molecule design and optimization, including a deep understanding of SAR, ADME, pharmacokinetics, and drug metabolism principles. Proficiency in interpreting complex biological and ADME data to inform compound design. Excellent communication, interpersonal, and presentation skills, with the ability to effectively interact with multidisciplinary teams and present complex scientific data to diverse audiences. Highly organized, detail-oriented, and able to manage multiple projects simultaneously in a fast-paced environment. Familiarity with computational chemistry tools and techniques (e.g., ligand-based and structure-based design). Extensive experience with outsourcing chemistry activities to CROs.