Associate Director/Director, LNP Formulation & Drug Product Development

nChroma Bio is a pioneering biotechnology company redefining the future of in vivo targeted genetic medicine to treat a wide array of diseases and bring cures to patients. The company’s integrated product engine tackles significant limitations of existing genetic medicine approaches by enabling safe, precise and specific in vivo delivery. nChroma’s near clinical-stage development candidate, CRMA-1001, is a liver-targeted therapy in development as a potential functional cure for chronic hepatitis B and hepatitis D that leverages the power of epigenetics, nature's innate mechanism for gene regulation. Guided by a world-class team at the forefront of genetic medicine, founded by renowned pioneers in the field, and supported by top-tier investors, the company is uniquely positioned to deliver groundbreaking therapies with programmable tissue specificity, unlocking highly potent, durable and targeted gene regulation for the liver and beyond.

We’re building a culture and organization to support this important mission, bringing together individuals that thrive in a supportive environment where diverse perspectives and a passion for discovery drive cutting-edge science and breakthrough medicines.

ABOUT THE ROLE

The incumbent will lead the development and optimization of nChroma’s LNP formulations and collaborate with both internal research teams and external CROs/CDMOs to support multiple programs. 

RESPONSIBILITIES

• Leverage both internal team and external CROs to optimize and produce high quality LNPs for our leading programs. Provide SME support for external production with our CDMO partners.


• Lead from the bench and develop a high-performing Formulation & PD team, including initiating excellent laboratory and documentation practice, providing hands-on support in the lab to train the team and run process operations, and provide mentorship and development opportunities for the team.


• Contribute as CMC Delivery representative for GMP production support & lead regulatory filing sections as needed. Collaborate with key stakeholders from payload, preclinical, manufacturing, analytical, and other internal functions to support program, department, and corporate goals.

SKILLS & COMPETENCIES:

• Impactful leadership skills and demonstrated ability to lead a diverse team.


• Excellent analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective.


• Strong oral and written communication skills with experience presenting scientific research.


• Ability to thrive in a fast-paced, innovative, and, at times, uncertain or changing environment while remaining flexible, proactive, and resourceful.


• Adept at prioritizing and managing multiple tasks simultaneously, integrating cross-functional issues, and balancing competing priorities effectively.


• Collaborative and team-oriented mindset with a desire to positively impact a new company’s evolving culture. Passionate, adaptable, and keen on working in the fast-paced biotech startup space to drive cutting-edge science.

QUALIFICATIONS:

• A minimum of 5 - 6 years in the biopharmaceutical industry with a proven track record of leading innovative nucleic acids delivery and formulation & scale up of LNP is required, including tech transfer to GMP suites.


• Advanced degree (MS or PhD) in Chemistry, Biophysics, Biochemistry, engineering, or related life sciences with strong scientific background.


• Experience in leading a team of direct reports and providing guidance and mentorship to junior scientists.


• Experience supporting development programs, including communicating between CMC and Program Teams.

Position Title and Salary will be commensurate with Experience

nChroma Bio is an equal opportunity employer, providing equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, nChroma Bio complies with applicable state and local laws governing nondiscrimination in employment.