Associate III, Analytical Development and Quality Control, Potency Assays

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

We are seeking a highly motivated Research Associate to support Quality Control (QC) testing of potency assays for our Antibody Drug Conjugate (ADC) portfolio. The primary responsibility of this role will be the execution of routine QC potency testing in support of release and stability programs. In addition, the Research Associate will support assay development, optimization, qualification and characterization testing activities for binding ELISA and cell-based cytotoxicity assays.

The ideal candidate will have hands-on experience with ADC cell-based potency assays, strong attention to detail, and an interest in working in a GMP-regulated environment. This role offers the opportunity to contribute directly to clinical-stage programs while gaining exposure to assay development, qualification, and method transfer activities.

Responsibilities

• Perform routine QC potency testing for ADC products, including execution of binding ELISA and cell-based cytotoxicity assays in support of release and stability testing.


• In collaboration with Contract Testing Labs (CTLs), develop robust potency methodologies to support ADC functional characterization, release and stability testing.


• Support assay development, optimization, and troubleshooting for binding ELISA and cytotoxicity assays under the guidance of senior staff.


• Assist with assay qualification, method transfer, and comparability activities, including data analysis and report preparation.


• Maintain laboratory readiness by following SOPs, managing reagents, maintaining equipment, and supporting general lab organization.


• Participate in the preparation and revision of SOPs, protocols, and technical reports to support QC and analytical development activities.


• Collaborate closely with cross-functional teams, including Analytical Development, Research, Quality Assurance, and external partners, to support project timelines and objectives.


• Contribute to continuous improvement efforts by identifying opportunities to enhance assay robustness, efficiency, and data quality.

Qualifications

• A bachelor’s degree in Molecular and Cellular Biology, Biochemistry, or a related field.


• A minimum of 5 years of relevant industry laboratory experience with at least 3 years of potency assay development and quality control testing.


• Hands on experience performing ELISA and/or cell-based assays; experience with cytotoxicity assays is plus.


• Familiarity with GMP, GLP, or regulated laboratory environments is preferred.

Knowledge and Skills

• Practical understanding of mechanism of action assay principles, including ligand-binding assays and cell-based functional assays.


• Experience with common laboratory techniques such as pipetting, cell culture, reagent preparation, and plate-based assays.


• Ability to analyze, interpret, and clearly present experimental data using standard software tools.


• Strong attention to detail and commitment to data integrity and documentation accuracy.


• Ability to follow established procedures while also contributing to assay optimization efforts.


• Effective communication skills and the ability to work collaboratively in a team-oriented environment.


• Strong organizational and time-management skills with the ability to manage multiple tasks in a fast-paced setting


• Position may require occasional evening and/or weekend work to support testing timelines.

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).