Job Description - Associate Scientist II, Conjugation Chemistry
Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales. Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members. Utilize UV-Vis spectroscopy and HPLC to analyze, purify, quantify, characterize, and formulate protein conjugates. Contribute to the maintenance of laboratory infrastructure and equipment. Support group organization, productivity, and expertise through collaboration and idea exchange. Meet quality, quantity, and timeline expectations for all assigned projects. Support discovery efforts in protein sciences. Maintain accurate and complete electronic notebook records. Communicate experimental plans and data to multiple cross-functional scientific teams. BS/MS degree in biology, biochemistry, biophysics, chemistry, or a related field, with 0-1 years of relevant laboratory experience in a biopharma or academic setting. Experience with modern bioconjugation chemistry and analytical techniques. Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV-Vis spectrometry. Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV-Vis spectroscopy) and label-free binding techniques (SPR and/or BLI) preferred. Experience developing new chromatographic methods is a plus. Knowledge of protein purification using ÄKTA systems preferred Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems. Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting. Effective written and oral communication skills.
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