Associate Scientist, In Vivo Pharmacology

Salary :

$120,000 - 140,000 yearly

Company : Parvus Therapeutics

Job Type : Full Time

South San Francisco, Ca

Job Description - Associate Scientist, In Vivo Pharmacology

Associate Scientist, In Vivo Pharmacology
Location: South San Francisco, CA (On-site)

Parvus Therapeutics Inc.

Parvus Therapeutics Inc. is a privately held biopharmaceutical company developing Navacims™, a platform technology based on foundational research published in 2016 (Nature 530:434), to treat autoimmune diseases. Parvus’ mission is to shift the treatment paradigm toward Navacim™-directed immune regulation, avoiding non-specific immune suppression associated with current therapies. Parvus’ innovative approach has the potential to benefit millions of patients suffering from debilitating autoimmune diseases and other chronic inflammatory conditions. Parvus is advancing a pipeline of proprietary drug candidates for multiple autoimmune indications through preclinical development and into the clinic. Parvus’ leadership team is experienced in successful drug discovery, development, manufacturing, regulatory approval, and commercialization.

The Position

We are seeking an Associate Scientist to help drive projects enabling the preclinical PK/PD characterization of pMHC NP towards clinical and combination therapy evaluation. This role will also establish model development to foster our clinical pipeline growth and life cycle management.

Primary Responsibilities:

Lead in vivo PK/PD model development or execution including biospecimen collection, processing, and analyses.
Serve as study monitor or study lead for IND-enabling studies performed in-house.
Write and amend IACUC protocols and internal SOPs as necessary.
Liaise with vivarium staff as necessary.
Oversee animal vendors, CROs, and diagnostic labs to ensure timely completion of non-GLP in vivo studies.
Participate in all aspects of vivarium and lab operation, training, and compliance including external audits where applicable.
Other duties and responsibilities as assigned.

Requirements:

Bachelors degree with a minimum of 8 years of experience or Masters degree with a minimum of 6 years of experience in Immunology or other relevant life sciences (2 years must be in biotech or industry setting).
Familiarity with animal handling, survival blood draws (lateral tail vein, facial/maxilliary/submandibular), terminal blood draws (cardiac puncture), and dosing methods including i.v., s.c., i.p., and p.o. a must.
Independently execute immune models in relevant rodent species including but not limited to type 1 diabetes, colitis, lupus, rheumatoid arthritis, and multiple sclerosis.
Experience running GSP/”GLP-like” studies suitable for regulatory submissions including gross necropsy and tissue preparations for histopathology.
Nice to have:
- Knowledge of surgical techniques including transplantation and portal vein infusion
- Experience with common bioanalytical methods such as Ligand binding assays, flow cytometry
- Experience writing study reports
Excellent oral, written communication, and presentation skills.
Demonstrated ability to effectively work in cross-functional teams, meet deadlines, and prioritize multiple projects is required.
Comfortable working collaboratively in a small, fast-paced environment.
Ability to quickly adjust to shifting project demands and priorities.

The expected annual salary range for this role is $120,000 – $140,000. Actual pay will be determined based on experience, qualifications, geographic location, business needs, and other job-related factors permitted by law.

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Associate Scientist, In Vivo Pharmacology

Job Description - Associate Scientist, In Vivo Pharmacology

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