Salary :
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Zenas is a clinical-stage global biopharmaceutical company committed to becoming a leader in the development and commercialization of transformative therapies for patients with autoimmune diseases. Our core business strategy combines our experienced leadership team with a disciplined product candidate acquisition approach to identify, acquire and develop product candidates globally that we believe can provide superior clinical benefits to patients living with autoimmune diseases. Zenas is advancing two late-stage, potential franchise molecules, obexelimab and orelabrutinib. Obexelimab, Zenas’ lead product candidate, is a bifunctional monoclonal antibody designed to bind both CD19 and FcγRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. We believe that obexelimab’s unique mechanism of action and self-administered, subcutaneous injection regimen may broadly and effectively address the pathogenic role of B cell lineage in chronic autoimmune disease. Orelabrutinib is a potentially best-in-class, highly selective CNS-penetrant, oral, small molecule Bruton’s Tyrosine Kinase (BTK) inhibitor with the potential to address compartmentalized inflammation and disease progression in Multiple Sclerosis (MS). Zenas’ earlier stage programs include a preclinical, potentially best-in-class, oral, IL-17AA/AF inhibitor, and a preclinical, potentially best-in-class, oral, brain-penetrant, TYK2 inhibitor.
We are seeking top talent who share our commitment to patients and have a track record of success in acquiring, developing and commercializing products across the globe. Our colleagues have an opportunity to engage in a fast-paced learning environment and experience individual and organizational success as we work towards becoming a global immunology and autoimmune disease leader, while living our values of Transparency, Relationships, Urgency, Excellence and Innovation – TRUE Innovation!
Position Summary:
The Commercial Supply Chain Planning and Operations Director will play a pivotal role in leading commercial planning and execution for Zenas’ first commercial product in the U.S. and the EU. This individual will be responsible for developing and maintaining end-to-end commercial supply plans, production schedules, and inventory strategies to ensure seamless product availability at launch and beyond. In addition, this individual will lead cross-functional launch planning and readiness activities to ensure operational and supply chain readiness for successful product launch in both the U.S. and EU.
This role will collaborate closely with Commercial, Technical Operations, Quality, Regulatory Affairs, CMC, and Finance, as well as external partners and CDMOs. The successful candidate will actively lead and drive the Sales & Operations Planning (S&OP) process for the commercial portfolio, develop and maintain performance metrics, and lead scenario modeling to optimize supply strategies aligned with regulatory filings, market forecasts, and business objectives
Key Responsibilities:
- Lead cross-functional commercial supply and launch readiness activities for the first product launch in the US and EU.
- Develop, drive and maintain detailed launch plans ensuring overall supply chain and CMC readiness for commercial launch.
- Build and maintain commercial supply models, forecasts, and capacity plans based on market demand, inventory strategies, and lead times.
- Coordinate with CDMOs to establish production schedules, campaign plans, and batch execution aligned to forecast requirements and contractual commitments.
- Lead monthly supply planning reviews and provide input into the S&OP process, highlighting risks, opportunities, and recommended actions.
- Partner with CMC, Quality, Regulatory, and Commercial to align supply strategies with registration timelines, market access, and forecast assumptions.
- Track and report key supply performance metrics (e.g., service level, plan adherence, capacity utilization, inventory health). Develop and implement supply chain dashboards, reports, and KPIs to support executive decision-making.
- Partner with Quality and Technical Operations to ensure compliant product release and distribution readiness.
- Support cost and budget management for commercial supply chain activities, including scenario-based financial impact modeling.
- Contribute to continuous improvement initiatives for planning systems, tools, and processes.
Qualifications:
- Bachelor’s degree in Supply Chain, Engineering, Life Sciences, or a related field (MBA or advanced degree preferred).
- Minimum of 12+ years in biotech or pharmaceutical supply chain management, with 3+ years in commercial or late-stage launch readiness.
- Proven experience managing CDMO relationships and external manufacturing operations (Drug Substance, Drug Product and Packaging and Labeling).
- Hands-on expertise in supply planning, launch planning, forecasting, and S&OP processes.
- Strong understanding of GMP manufacturing, regulatory submission impact on supply, and global distribution logistics.
- Excellent analytical and modeling skills; advanced skills in Excel and/or supply planning tools.
- Strong project management and cross-functional leadership capabilities.
- Exceptional communication and presentation skills, with the ability to synthesize complex information for senior stakeholders.
- Demonstrated ability to thrive in a fast-paced, dynamic, and matrixed environment.
- Comfortable managing ambiguity and building new processes from the ground up.
- Ability to work flexible business hours to travel and communicate with global business partners (up to 10-20% of time).
LI-Hybrid
The position is eligible for a competitive compensation and benefits package.
Zenas is committed to fair and equitable compensation practices. The base salary pay range for this role is $175,200 to $219,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.
Zenas believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Zenas’ competitive total rewards strategy that also includes annual performance bonus, equity, full range of benefits and other incentive compensation plans.
Zenas BioPharma is proud to be an equal opportunity employer. We are committed to fostering an environment where diversity is valued. All qualified applicants will receive consideration for employment based on merit, qualifications and the needs of the business.
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