Director, Early Commercial

Use Your Power for Purpose

In Global Commercial Strategy (GCS), we translate science into value for patients and Pfizer. GCS serves as the strategic engine and commercial voice across the asset lifecycle — shaping asset positioning and evidence generation, leading global launches, and driving sustained access and brand performance through market and payer insights, broad access, & commercial rigor. Whether you are defining strategy, managing brands at different lifecycle, or building the capabilities that power our commercial engine, your work directly shapes patient outcomes and the long-term success of Pfizer's portfolio.

Epstein-Barr virus (EBV) represents a significant area of scientific and commercial interest. EBV causes mononucleosis which is increasingly associated multiple sclerosis, systemic lupus erythematosus and several malignancies – all disease areas with significant unmet and promising potential for a prophylactic or treatment vaccine approach.

What You Will Achieve

This role is an individual contributor within the Vaccines Early Commercial Business, part of the Global Commercial Strategy organization, reporting to the Vaccines Disease Area Lead (DAL). The Director, Early Commercial, is the Commercial lead for Pfizer's pre-clinical EBV program responsible for leading the commercial strategy and progressing the emerging asset through governance stage-gates, endorsements, and prioritization decisions. Key responsibilities include, but are not limited to, comprehensively articulating the market opportunity and generating insights required to drive strategy, guide development decisions and inform long-range forecasting, as well as leading cross-functional alignment of a value-maximizing target product profile and on-going valuation processes to ensure the asset is appropriately prioritized at the enterprise level.

The role will partner closely with Research & Development, Medical Affairs, Global Access Strategy & Pricing, Business Analytics & Insights, Competitive Intelligence, Business Development, and US and International Commercial teams.

The role requires strong strategic judgment, critical thinking, and analytical rigor, combined with a solid scientific foundation capable of deeply understanding the complex and quickly moving science in this space. Cross-functional leadership and effective influence will be critical to shaping future program direction, priorities and, ultimately, maximizing public health impact with this unique opportunity.

Asset Leadership:

• Identify and champion key value drivers and relevant target populations for EBV opportunities, grounded in epidemiology and burden of disease, health economics, patient flows, and current standards of care

• Provide early and on-going read on competitive activity and implications

• Translate unmet need, standard of care, competitive dynamics, patient/HCP insights, and access considerations into differentiated commercial hypotheses - socialize and cross-functionally align Commercial POV

• Oversee market research plan to generate key insights and fill in knowledge gaps to directly shape product concepts, potential target product profile(s) and related clinical strategy

• Identify risks, uncertainties, and evidence needs that may impact future EBV asset potential

• Lead on-going development of cross-functionally aligned, value-maximizing target product profile

• Provide Commercial input to clinical development, evidence generation, lifecycle, and indication sequencing discussions

• Support the annual strategic and operating plan process, and manage associated Commercial budget

Commercial Assessment and Business Case Development:

• Lead development of commercial opportunity scenarios and related assessments, including market-sizing, competitive scenarios, price, market share, etc.

• Partner with R&D, BAI, GASP, and Competitive Intelligence colleagues to pressure-test assumptions and identify key decision points

• Continuously monitor the competitive landscape and highlight points of differentiation and Commercial implications - socialize and lead strategic discussions to align and execute updated action planning

• Develop clear, executive-ready materials that communicate Commercial opportunity, strategic rationale, risks, and investment implications

• As asset progresses into clinical stage, lead increasingly rigorous long-range forecasting and valuation

• Define and execute market research to inform forecast funnel and key inputs

• Support commercial assessments of external innovation and Business Development opportunities relevant to Pfizer Vaccines EBV interests

Cross-Functional Partnership and Governance:

• Strong representation of Commercial perspective throughout early development decisions and in all key decision points

• Lead Commercial preparation for governance forums, portfolio reviews, strategy discussions, and investment decision meetings

• Build trusted working partnerships across Research & Development, Medical Affairs, Global Access Strategy & Pricing, Business Analytics & Insights, Competitive Intelligence, Business Development, and US and International Commercial teams

• Influence and align stakeholders around shared objectives, strategic planning and decisions, including trade-offs

AI-Native Ways of Working:

• Use AI-enabled tools to support scientific and competitive landscape synthesis, market insight generation, scenario development, and strategy workstream efficiency

• Apply AI-augmented approaches to accelerate analysis, identify patterns across complex data sources, and improve quality and consistency of strategic outputs

• Employ innovative AI-enabled ways of working into early commercial strategy and decision-support processes

• Stay current on emerging tools and practices that can strengthen commercial strategy development and asset decision-making

Here Is What You Need (Minimum Requirements)

•  Applicant must have a bachelor's degree with at least 8 years of experience; OR a master's degree with at least 7 years of experience; OR a PhD with 5+ years of experience

• Experience in pharmaceutical, biotechnology, life sciences or strategic consulting (e.g., Commercial Development, Marketing, strategic consulting, analytics, forecasting)

• Ability to understand complex scientific and clinical data and translate implications for differentiation, commercial opportunity and asset value

• Proven leadership and demonstrated ability to drive cross-functional collaboration, challenge the status quo and manage stakeholders

• Strong strategic skills including ability to identify key issues early and address major challenges (e.g., emerging competition, shifting landscape)

• Adept at synthesizing complex scientific, clinical, market, access, and competitive information into clear insights, perspectives, recommendations and action plans

• Excellent interpersonal skills, verbal communication and presentation skills

• Ability to lead projects with no clear precedent roadmap and prioritize efforts across the team and the organization.

• Demonstrated ability to manage multiple priorities and deliver high-quality work in a matrixed environment.

• Demonstrated ability to make decisions with limited information and propose alternative scenarios or mitigation strategies

• Comfort working in an AI-native or AI-augmented environment

Bonus Points If You Have (Preferred Requirements)

• Advanced degree in life sciences or business

• Experience in Vaccines

• Strong forecasting skills, understanding P&L and valuation metrics

• Experience developing business cases or strategic options for senior decision makers
   

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Some travel (up to 20%)

Work Location Assignment: Hybrid

The annual base salary for this position ranges from $176,600.00 to $294,300.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

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