Director, R&D FP&A

The Position 

We are seeking a Director, FP&A to serve as a strategic finance partner to our R&D organization.  In this highly visible role, you will support critical investment decisions across our development portfolio by delivering financial insights, forecasting, and decision support. 

You’ll work closely with R&D and finance leadership to translate scientific and clinical strategies into actionable financial plans, helping ensure resources are deployed effectively across programs. 

This role reports to the Sr. Director of FP&A and follows a hybrid scheduled of two-to-three days per week in office. 

The Impact You’ll Have 

Strategic Partnership & Decision Support 

• Partner with R&D leadership and project teams to develop portfolio and program-level financial plans 


• Lead scenario modeling, cost-benefit analyses, and vendor investment decisions 


• Support clinical program investment decisions and other high-priority strategic initiatives 

Financial Planning & Analysis 

• Deliver accurate and timely forecasts, budgets, and long-range plans for R&D functions 


• Prepare and present financial analyses to senior leadership, including materials for Board meetings 


• Provide variance analysis and actionable insights to inform decision-making 

Cross-Functional Collaboration 

• Partner closely with Accounting to align budget vs actuals, including accruals, coding, and variance reporting 


• Collaborate with functional stakeholders to translate scientific and operational plans into financial outcomes 

Process Improvement & Systems 

• Drive improvements in FP&A processes, reporting, and forecasting accuracy 


• Partner with the Head of FP&A to enhance and automate allocation methodologies across programs and indications 

As a Director, we also expect our leaders to demonstrate the following Leadership Competencies:

• Communication and Influence 
  
  
  
  • Builds communication channels across Maze for sharing information. 
  
  
  • Influences Senior Management decisions through persuasive arguments. 
  
  
  • Respectfully addresses differing opinions leading to support of decisions. 
  
  
  
  


• Teamwork and Collaboration 
  
  
  
  • Champions partnerships and connections across Maze. 
  
  
  • Proactively addresses issues that could result in breakdown of team relationships. 
  
  
  • Spotlights team and individual contributions in public forums. 
  
  
  
  


• Execution and Results 
  
  
  
  • Addresses gaps and leverages strengths to get best results. 
  
  
  • Maintains a steadying presence and clarifies priorities during change. 
  
  
  • Anticipates and removes barriers that put functional/corporate goals at risk. 
  
  
  
  


• Develop Others and Self 
  
  
  
  • Remove barriers to staff development and empowers them to make their own decisions. 
  
  
  • Stays current on industry trends and keeps direct-reports prepared and responsive. 
  
  
  
  

What We’re Looking For

Experience & Background 

• Bachelor’s degree in Finance, Accounting, Economics, or related field; MBA or equivalent experience preferred. 


• 10+ years  of experience in the pharmaceutical or biotech industry, including significant FP&A experience 


• Experience supporting R&D or development organizations strongly preferred 


• Clinical trial forecasting and accruals experience preferred 

Technical & Analytical Skills 

• Advanced proficiency in Excel and PowerPoint 


• Experience with financial systems such as NetSuite, Coupa, and Anaplan, or similar tools 


• Strong financial modeling and forecasting capabilities, including ad hoc analysis 

Business Partnership & Communications 

• Proven ability to build strong relationships and influence cross-functional stakeholders 


• Ability to translate complex scientific and strategic concepts into clear financial insights 


• Excellent written and verbal communication 

Execution & Mindset 

• Highly organized with the ability to manage multiple priorities and meet deadlines 


• Detail-oriented and solution-driven, with a focus on continuous improvement 


• Collaborative mindset with a focus on improving efficiency and effectiveness 


• Interest in exploring applications of AI to enhance FP&A processes 

This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters two-to-three days per week.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.  

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.  

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. 

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $227,000 to $277,000. Additionally, this position is eligible for an annual performance bonus.  

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.  

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy. 

#LI-Hybrid