Director, Real World Evidence, Global Rare Diseases - HIDO

This is what you will do

The Director, RWE is responsible for leading and executing the global RWE strategy and vision for the Hematology, Immunology, Dermatology and Ophthalmology (HIDO) Portfolio within GRD, ensuring the strategy, creation and updating of the integrated evidence generation plan (IEGP), in alignment with cross-functional partners to meet research and commercial objectives. This role drives enterprise-level RWE impact, including building strategic data partnerships, advancing innovative methodologies, and influencing cross-functional decision-making.

You’ll be responsible for:

RWE Strategy & Leadership

Act as a change agent, effectively communicating the value of RWE and influencing adoption of new processes and approaches.  This includes:

• Lead the global RWE strategy for the HIDO GRD portfolio, acting as the strategic RWE leader across development, regulatory, and commercialization phases, and ensuring its integration into regulatory, payer, and clinical decision-making across the HIDO Portfolio including Iron overload (e.g., beta‑thalassemia, SCD) Therapeutic Area (TA), Epidermolysis bullosa TA, Leber’s Hereditary Optic Neuropathy TA,  and future pipeline or acquired assets.   


• Increase the integration of RWD sources to enhance evidence-based decision making through research programs, while providing medical leadership as appropriate on cross-functional teams supporting local and global needs in a prioritized manner.


• Publish, where appropriate in high impact journals.

 Capability Building & Organizational Leadership

• Continuously improve RWE capabilities, processes, and infrastructure to support global and local evidence generation for HIDO Build and scale RWE capabilities as a competitive advantage for GRD


• Establish best practices, standards, and ways of working across regions


• Lead change management to embed RWE into core organizational processes

 External Data & Partnership Strategy

• Lead identification, evaluation, and execution of external RWD partnerships and data acquisition strategies


• Oversee due diligence, contracting support, and governance of external data sources and collaborations


• Build long-term strategic relationships with academic institutions, data vendors, consortia, and healthcare systems

 Scientific & Technical Leadership

• Foster the appropriate use and adoption of appropriate analytic technologies to improve RWE reliability and applicability to provide insights that matter to internal and external stakeholders


• Provide senior scientific leadership and deep technical expertise in observational research, epidemiology, and RWE methodologies


• Guide study design, analytics strategy, and interpretation of evidence


• Ensure adoption of innovative approaches, including AI/ML and advanced analytics, in RWE generation

 Cross-Functional Influence & Integration

• Act as the RWE subject matter expert within cross-functional teams (Medical, Clinical Development, Market Access, Regulatory)


• Influence asset strategies, development plans, and access strategies


• Lead alignment of RWE priorities across global and regional stakeholders

Evidence Generation Oversight

• Provide executive oversight of RWE studies, registries, and non-interventional programs, ensure studies are aligned to strategic priorities and deliver high-impact outcomes


• Maintain governance of study concept development and prioritization

External Scientific Leadership & Visibility

• Represent Chiesi externally in scientific forums, consortia, and partnerships


• Drive publication strategy and dissemination of RWE insights


• Maintain awareness of emerging trends, regulatory guidance, and methodological advances

Leadership & Matrix Management

• Lead cross-functional and multidisciplinary teams in a matrix environment


• Oversee budgets, timelines, and resource allocation across RWE initiatives


• Manage consultants, mentor junior team members and as needed, direct reports over time

You will need to have

• Advanced degree (PhD, DrPH, MD, PharmD, MSc) in epidemiology, public health, health economics, or related field


• 8+ years of experience in RWE, HEOR, epidemiology, or observational research in pharma/biotech or related setting


• Demonstrated success in leading RWE strategy at asset or portfolio level


• Strong experience in real-world data sources (claims, EHR, registries, etc.)


• Proven track record of building partnerships and influencing senior stakeholders


• Experience supporting regulatory and/or market access use of RWE


• Deep expertise in epidemiology and RWE methodologies


• Ability to translate evidence into business and clinical impact


• Demonstrated ability to influence senior stakeholders and cross-functional leadership


• Strong executive communication skills


• Experience with advanced analytics, AI/ML, and innovative RWE approaches


• Ability to shape data strategy and infrastructure decisions


• Strong governance and oversight of complex, multi-country studies and programs


• Ability to manage competing priorities and large-scale initiatives

We would prefer for you to have

• Rare disease experience strongly preferred; experience in hematology, immunology, dermatology, ophthalmology, or specialty medicines highly desirable.

Location

Hybrid role based in Boston, MA office. Up to 20% domestic and international travel availability required. #LI-Hybrid

Compensation

The annual base pay for this position ranges from $181,000 to $271,000. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. If hired, the employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.