Director/Sr. Director, Clinical Pharmacology

BBOT is a private biotech company dedicated to developing innovative new therapeutics to address dire unmet needs in oncology. Founded on a commitment to patients, scientific excellence, and operational agility, we understand that every minute counts in our efforts to develop new therapies to transform the lives of people living with cancer. Driven by a team of experienced scientists, clinicians, and industry experts, our team utilizes cutting-edge structure-based drug discovery techniques to target some of oncology’s most challenging and validated molecular targets, including KRAS and PI3Ka. BBOT has a pipeline of several promising differentiated drug candidates and strong investor support, the combination of which positions us to deliver meaningful benefit to patients. Our offices and laboratory are in South San Francisco, though our colleagues and collaborators span the country and globe.

We are seeking an experienced and visionary Senior Director/Director of Clinical Pharmacology to lead clinical pharmacology efforts to support multiple oncology programs. 

• Lead the clinical pharmacology strategy for multiple oncology programs, ensuring alignment with regulatory requirements and scientific standards.
• Design and oversee clinical pharmacology studies to support multiple oncology program clinical development.
• Collaborate with cross-functional teams, including clinical operations, biostatistics, and regulatory affairs, to drive the advancement of drug development programs.
• Provide expertise in the interpretation of PK/PD data and its implications for clinical trial design and dose selection.
• Author relevant sections/modules of regulatory documents (including INDs, IBs, CTAs, IMPDs, NDAs, briefing packages, or other regulatory dossier) and participate in interactions with regulatory authorities. 
• Stay abreast of industry trends and advancements in clinical pharmacology and oncology, contributing to the scientific community through presentations and publications.

• Ph.D. or equivalent in pharmacokinetics (PK)/pharmacodynamics (PD), Pharmacology, Chemistry, or a related field. 
• Minimum of 10 years of experience in clinical pharmacology, particularly with small molecule modality within the oncology therapeutic area.
• Proven track record of successfully managing clinical pharmacology studies and developing regulatory submissions.
• Strong understanding of oncology drug development processes and regulatory guidelines. 
• Quantitative pharmacology skillset preferred, e.g. PBPK, PK/PD modeling, population PK, and exposure-response analyses.
• Excellent communication and interpersonal skills, with the ability to work collaboratively in a team environment.

The annual salary range for this position is $220,500 - $307,500 in the San Francisco Bay Area. BBOT considers a variety of factors when determining base compensation, including experience, skills, education, qualifications, and geographic location. Actual compensation will vary, and it is not typical to be hired at or near the top of the range for the role. 

Base compensation is part of a robust total rewards offering at BBOT. Additional total rewards elements include annual bonus, stock-based long-term incentives, medical, dental, and vision benefits, retirement, wellness stipend, and flexible time off.