Equipment Engineer

Equipment Engineer (onsite in South San Francisco, CA )

Job Description

The Equipment Engineer is responsible for ensuring the reliability and performance of all production instrumentation within a high-throughput DNA synthesis environment. You will be the primary lead for validating equipment, performing routine and preventative maintenance, and executing complex troubleshooting to minimize downtime.The ideal candidate is a self-motivated problem-solver who thrives in a fast-paced setting and is committed to maintaining the rigorous quality metrics required for cutting-edge biotechnology production.

What You’ll Be Doing

• Equipment Validation: Lead the execution of Installation Qualification (IQ), Operational Qualification (OQ), and Performance Qualification (PQ) for both new and existing instrumentation.


• Preventative Maintenance: Manage the scheduling and execution of routine maintenance and calibrations in strict accordance with manufacturer specifications and internal quality standards.


• Troubleshooting: Investigate recurring equipment failures to implement permanent engineering fixes, significantly reducing or eliminating downtime.


• Quality Compliance: Own and ensure the timely closure of equipment-related CAPAs (Corrective and Preventive Actions) and Change Controls.


• Inventory & Logistics: Instrument, spare part, and service purchasing, from order submission to receipt of goods.


• Cross-Functional Collaboration: Partner closely with Process Engineers to understand equipment-process interactions and ensure hardware operates within peak specifications.

What You’ll Bring to the Team

• Education: BS in Engineering, Physical Sciences, or a related technical discipline.


• Experience: Minimum of 1-3 years of professional experience in equipment maintenance, calibration, and repair.


• Technical Versatility: Proven ability to design and build projects to improve reliability using mechanical, electrical, and electro-mechanical systems


• Quality Mindset: High attention to detail and strong organizational skills; experience working under ISO 9001, ISO 13485, or GMP/cGMP standards is highly preferred.


• Adaptability: Ability to multi-task in a dynamic environment and work comfortably in a cleanroom setting (requiring lab coats, hairnets, and gloves).


• Good computer skills (Excel, Word, Atlassian etc) and the ability to quickly learn new software applications.


• Communication: Excellent interpersonal skills with a collaborative approach to problem-solving.


• Strong documentation experience, drafting technical documentation, and managing maintenance records.


• Bonus Assets: Experience with automated liquid handlers, robotics, or MES/LIMS integration is a significant plus.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.