Executive Director, Pharmacometrics

Develop and implement pharmacometric strategies across drug development, including dose selection, study design, and lifecycle management. Provide scientific modeling based input in interpretion and translation of preclinical information to clinical for novel indications and target tissues Lead and mentor a team of pharmacometricians, ensuring their professional development and providing guidance on complex analyses Partner with cross-functional teams (early development, clinical research, clinical pharmacology, biostatistics, regulatory affairs) to advance Alnylam portfolio against program goals. Lead the development and application of pharmacometric models to support dosing decisions, optimize trial designs, establish proof of concept and optimize clinical trial success. Engage with regulatory agencies and prepare and review pharmacometric reports and regulatory submission documents. Stay current with advances in pharmacometrics and share expertise within the organization. PhD or equivalent in clinical pharmacology, pharmacokinetics, or pharmacometrics 10+ years of pharmaceutical industry experience in drug discovery and development Expert knowledge of PK/PD, QSP and pharmacometric analyses Proficient in using modeling software such as R, NONMEM, SAS, MATLAB Ability to manage multiple programs Excellent problem solving skills with a strong innovative spirit Strong leadership and interpersonal skills with experience managing a team of pharmacometricians Excellent oral and written communication skills Experience with writing Clinical Pharmacology and Pharmacometrics documents supporting regulatory submissions