Genomics Scientist

Overview:

Business Title: Genomics Scientist

Position Title: Analyst IV

Division: Consumer Products Services

Entity: ATL

Location: Boston, MA

Reports to: Manager

FLSA: Non-exempt

Hours Worked: Typically, Monday through Friday, forty-hours per week. However, must be flexible to meet the needs of the department and complete other projects as assigned.

Position Summary:

The Genomics Scientist is responsible for building and validating NGS-based assays that characterize the genomic safety of next-generation gene editing technologies. This role will design and implement molecular and genomic assays, develop automated NGS library preparation workflows using liquid handling platforms, and support IND/CTA regulatory submissions. Working cross-functionally with the off-target biology team, this role will apply expertise in primer/probe design, amplicon and hybrid-capture sequencing, and structural variant detection across primary cells, iPSCs, and in vivo samples.

Duties and Responsibilities:

It is everyone’s responsibility to live out our Values and Absolutes by Shaping a World of Trust while ensuring responsible progress.

• Build and onboard molecular and genomic assays to characterize genomic safety of next-gen template-based editing technologies.


• Skilled in molecular biology techniques including primer/probe design for Amplicon sequencing, digital PCR and cloning to support NGS assay development.


• Experience designing and validating NGS-based assays (e.g., targeted amplicon and hybrid-capture sequencing) for off-target and structural variant detection.


• Proven ability to automate and scale NGS library preparation and molecular biology workflows using liquid handling platforms (Agilent Bravo, Biomek FXP, Hamilton) across primary cells, iPSCs, and in vivo samples.


• Work in a highly cross-functional set-up to deliver genomic safety assessments in an agile and timely fashion.


• Work with the head of the off-target biology team to develop novel assays that characterize genomic safety across gene editing modalities.


• Maintain detailed documentation of scientific work in an electronic notebook.


• Perform final review and interpret data / reports. Perform critical error review.


• Review and close root cause analysis and corrective actions.


• Works directly with external contacts to implement new testing or process initiatives.


• Assist in the coordination of technical & administrative aspects of various departmental projects, providing direction to techs. 


• Perform background/literature research to help further research goals.


• Write, implement and update SOPs, test protocols, and technical procedures to facilitate department  development and improve quality.

Skills & Proficiencies:

• Strong experience operating Illumina NGS platforms (NovaSeq, NextSeq, MiSeq) and designing custom NGS library prep workflows (targeted amplicon, hybrid capture, UMI-based error correction)


• Experience with human primary cell and iPSC culture, LNP and electroporation-mediated delivery


• Deep proficiency in using Geneious Prime for primer/probe design and cloning workflows, FlowJo, and GraphPad Prism; Python scripting for NGS data analysis; experience with automated liquid handling scripting a strong plus.


• Written and verbal communication skills including the ability to communicate effectively in a group setting, with colleagues and clients


• Organizational and time management skills


• Ability to perform multiple tasks 


• Ability to organize and prioritize workload to meet or exceed deadlines


• Individual and Team work ethic 


• Proficiency with Windows, Word & Excel 


• Attention to detail 


• Positive attitude, self-motivated, high level of engagement


• Champions company values including team engagement


• Ability to present both facts and recommendations effectively


• Technical problem solving and process improvement skills 


• Strong interpersonal skills – being approachable, relationship building with external and internal contacts, demonstrating initiative and adaptability 


• Ability to train on all technical aspects in data analysis in the assigned laboratory

Education and Experience:

• Bachelor’s in biology or closely related field


• Minimum of four years of experience with NGS, molecular biology (primer design, cloning), and automated laboratory workflows

An equivalent combination of education and experience may be accepted in lieu of above.

Compensation Range: $45.00-$50.00 per hour  (e.g., the job posting is not necessarily reflective of actual compensation that may be earned, and actual compensation is subject to variation due to such factors as location, education, experience, and skillset).