Head of Platform

About Proxima

Proxima (formerly VantAI) is advancing an AI-native approach to drug discovery by making protein interactions programmable. Our platform brings together foundation-model machine learning, a scalable data generation engine, and a partnership track record exceeding $5B in collaborations across the world’s leading biopharma and tech organizations. We’ve recently closed an oversubscribed seed round partnering us with an elite group of sophisticated and dedicated VCs including DCVC, Nvidia’s Nventures, AIX, Yosemite among others.

Neo-1 is our all-atom foundation model that combines state-of-the-art structure prediction and molecular generation in a single system. Neo-1 enables rapid exploration of chemical and structural space for high value, previously intractable targets, and in particular unlocks small molecule proximity therapeutics like molecular glues with AI for the first time.

In parallel, we are developing an advanced structural interactomics platform built on proprietary XLMS technology and a lab equipped with next-generation mass spectrometry instrumentation. This platform produces proteome-scale maps of protein interactions and helps identify small molecules that modulate proximity. Together with Neo-1, it creates an integrated system capable of co-folding protein complexes while generating candidate small molecules to influence those interactions.

Proximity-based therapeutics represent one of most promising frontiers in modern drug discovery with the potential to treat previously intractable diseases and target ‘undruggable’ proteins. Our technology combines proteome-scale structural data with state-of-the-art generative AI foundation models, and coupled with our talented team of scientists and engineers we are uniquely well-positioned to discover and develop a new class of medicines. Come join us!

About the role:

We're looking for a Head of Platform, a leader with a deep understanding of proteomics and small molecule drug discovery who can help us scale one of the most exciting screening and data generation platforms in a novel modality. Join us!

Key Responsibilities: 

• Drive the scientific strategy, aligning our proteomics research with AI-driven drug discovery initiatives.

• Lead and nurture a team of PhD researchers, promoting a culture of innovation and discovery.

• Oversee lab operations and facilities, maintaining an environment that fosters excellence and safety.

• Plan and steer ambitious proteomics experiments, making key decisions to shape our scientific trajectory.

• Prudently invest in state-of-the-art lab hardware to keep us on the cutting edge of proteomics research.

• Bridge the gap between lab teams and computational workstreams, fostering a synergistic environment that maximizes data utility.

• Manage and optimize the lab budget, ensuring resources are strategically allocated.

• Provide regular updates on scientific progress, keeping stakeholders informed and inspired.

 Required Qualifications:

• PhD in Chemical Biology, Proteomics, or related field.

• Proven experience in proteomics research and small molecule drug discovery. 

• Track record in designing and executing complex scientific experiments.

• 5+ years in industry experience focused on small molecule drug discovery at pharmaceutical or biotech companies, with a track record in leading small molecule proteomic initiatives. 

• Computational affinity, worked with computational biologists.

• Experience in managing a team of PhD researchers.

• Familiarity with AI applications in proteomics and drug discovery.

• Strong budget management skills.

• Excellent communication skills, adept at summarizing scientific progress for various audiences.

Desired Skills:

• Experience in a high-tech or AI-driven company.

• Understanding of computational biology or bioinformatics.

• Proven track record in setting up new labs or expanding existing facilities.