Principal Associate Scientist, Research (RNAi Biology & siRNA Delivery)

The candidate will engage in a variety of mechanistic in vitro and in vivo siRNA research efforts to evaluate RNAi compounds, utilizing biochemical, molecular, and cell-based assays. Design, execution, interpretation, and troubleshooting of experiments on an individual basis as well as part of a collaborative team. Presentation of results in both written and oral format to key stakeholders within the Research organization. BS/MS in Biology, Biochemistry, or related field with 6+ (BS) or 4+ (MS) years of work experience, preferably in industry setting Prior experience and/or working knowledge of nucleic acid-based therapies (siRNA, ASO, CRISPR) is highly desired. Proficiency in mammalian immortalized and primary cell culture (maintenance, transfection/stable selection). Proficiency in DNA/RNA squence evaluation and plasmid design. Proficiency in routine molecular biology assays to support evaluation of siRNA acitvitiy (qPCR, Western Blotting, ELISA, Ago-immunoprecipitation, etc.). Prior experience with advanced cell models, including generation and/or CRISPR editing of iPSC-derived cell lines would be highly valuable. Molecular biology assays to support evaluation of siRNA activity (qPCR, Western blotting, ELISA, Ago-immunoprecipitation, etc.). Experience with (or willingness to learn) in vivo rodent handling and experimentation is a plus. Excellent lab technique and ability to work independently. Strong interpersonal skills and excellent communication skills (written and oral) are required.