Process Chemist, Associate Director

About Us

Our team is dedicated to the development of a broad pipeline of small molecules powered by unique chemistry insights to address a wide range of high unmet clinical needs.

Our company was created within 5AM Ventures' 4:59 Initiative in 2023.  We are based in Watertown, MA with state of the art, custom lab and office space.

• In this newly created role, you will be tightly integrated in a cross-functional drug discovery team making substantial contributions in chemical process optimization and scale-up
• As the first hire for Process Chemistry, you’ll set the foundation for the function
• Lead the design, optimization, and scale-up of chemical processes to meet production goals while adhering to safety, quality, and regulatory requirements.
• Propose R&D direction in optimization, develop scalable process and implement the optimized condition into manufacturing
• Conduct thorough analysis of process data, identify optimization opportunities, and implement innovative solutions to enhance process efficiency and productivity
• Design and execute experiments to troubleshoot process issues, investigate deviations, and implement corrective actions to ensure continuous improvement

• You have spent at least 10+ years gaining industry experience in pharma and/or biotech, operating in a multidisciplinary drug discovery team environment
• You’ve earned your Ph.D. in Organic Chemistry or Synthetic Chemistry
• You are excited about being in the lab consistently and rolling up your sleeves to contribute to drive scale-up capabilities
• Proven track record of successfully leading process optimization, scale-up, and technology transfer initiatives
• In-depth knowledge of chemical process principles, reaction kinetics, and unit operations, with hands-on experience in process modeling and simulation tools
• Experience with multi-gram synthesis utilizing flow chemistry is required
• In-depth knowledge of modern-day technologies, with a specific focus towards single-electron methodologies is preferred
• Experience coordinating and collaborating with CMC and CRO consultants
• You’re a team player first, and you’re also someone who can easily flex to work independently to conduct research
• Your colleagues would describe you as an open and articulate communicator
• You bring an openness to learn from diverse perspectives and collaborate on multidisciplinary teams
• You have a track record of scientific vigor and creativity in carrying out research

We are an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected characteristics.