Senior Medical Science Liaison (MSL) - Northeast

Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.

Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.

Description of Role

The Sr. MSL will serve as a field-based scientific expert responsible for engaging with healthcare professionals (HCPs), supporting clinical development, and ensuring alignment with Centessa’s strategic medical objectives. This role is critical in translating complex scientific data into meaningful clinical insights and fostering compliant, evidence-based dialogue with thought leaders.

Key Responsibilities

Scientific Expertise & Thought Leader Engagement

• Maintain a high level of therapeutic area expertise and scientific knowledge relevant to Centessa’s pipeline and marketed products in alignment with Medical Affairs strategic objectives


• Engage in compliant, non-promotional scientific exchange with key opinion leaders (KOLs), investigators, and other HCPs


• Serve as a trusted scientific resource to external stakeholders, providing accurate and balanced medical information


• Deliver company-approved, high-quality medical/scientific presentations to a variety of audiences including formulary committees and healthcare professionals.


• Provide medical/scientific support for critical Centessa activities including speaker training, advisory boards, and sales training as appropriate


• Ensure accurate, timely, and compliant documentation of field-based activities in accordance with MSL organization guidelines

Clinical Trials Support

• Collaborate with Clinical Operations to identify and evaluate potential clinical trial sites and investigators based on scientific expertise, patient population, and alignment with study objectives


• Provide scientific education and protocol-specific training to investigators and site staff during site initiation visits, ensuring thorough understanding of study rationale and endpoints


• Maintain ongoing engagement with trial sites and investigators to facilitate successful execution of clinical trial objectives, provide ongoing scientific support, address protocol-related inquiries, and ensure high-quality data generation

Medical Conference Attendance & Coverage

• Attend relevant scientific and medical congresses to stay current with emerging data and trends


• Provide real-time insights and post-conference reports to internal teams


• Support Centessa’s presence at congresses through development of pre-conference plans, booth coverage, symposia participation, and KOL engagement


• Senior MSLs will be responsible to leading strategic conference planning, execution, and reporting

Scientific Materials Development

• Contribute to the development of scientific slide decks, FAQs, and educational materials


• Writing and editing Medical Information response letters


• Ensure all materials are medically accurate, evidence-based, and compliant with regulatory standards


• Collaborate with Medical Affairs and Legal teams to ensure scientific content meets internal and external guidelines

Additional Responsibilities:

• Lead MSL strategic initiatives/projects aligned with Medical Affairs and MSL organization strategy


• Develop and implement scientific training plans for the MSL team


• Contribute to MSL organization strategy in collaboration with MSL leadership


• Mentorship of MSL peers

Qualifications

• Advanced degree (PhD, PharmD, MD, DP, PsyD, DNP) in life sciences or a related field (from An Accredited College or University).


• Minimum 4+ years' experience as an MSL for a drug development company in the pharmaceutical/biotech industry


• Demonstrated understanding of sleep medicine and/or associated neuroscientific areas required 


• Exceptional verbal and written communication skills; ability to tailor scientific messages to diverse audiences and ability to interpret and communicate complex scientific data


• Proven ability to build and maintain strong relationships with KOLs, investigators, and internal stakeholders


• Strong understanding of clinical trial design, regulatory requirements, and therapeutic area landscape


• Skilled in developing and delivering scientific presentations in various settings


• Strong understanding of industry regulations and guidelines governing medical interactions


• Ability to align field activities with broader medical and corporate strategies


• Senior MSLs have a proven ability to lead and mentor peers


• Must have a valid driver’s license with a driving record that meets company requirements


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  Must reside within the New England region or the New York Metro area.
  
  


• Willing and able to travel frequently within assigned territory (Boston, New York, Philadelphia, Baltimore, Detroit, Cleveland, Cincinnati)

Compensation

The annual base salary range for the Senior MSL job level is $190,000 - $230,000.

Individual compensation within these ranges will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.

In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.

Work Location

The Sr. MSL - Northeast is a remote role based in the US, with up to 60-70% travel and occasional weekends

POSITION: Full-Time, Exempt

EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.