Research Associate/Senior Research Associate, In Vivo Pharmacology

Manifold Bio is a dynamic biotech company building a pipeline of  targeted biologics using a novel in vivo-centric discovery approach. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.

Position

We are seeking a highly-motivated In Vivo Pharmacology Senior Research Associate  who thrives in a fast-paced and creative environment to push the capabilities of our multiplexed in vivo drug discovery platform. Together with senior researchers, you will play a critical role in executing in vivo studies to support internal research projects. This is a hands-on role and you should have extensive experience in multiple aspects of in vivo pharmacology including dosing, necropsy, perfusion, tissue collection and  sample processing, among others. The ideal candidate must be able to work effectively both in a collaborative setting and independently. 

Responsibilities

• Conduct in vivo mouse studies, including dosing via IV, IP, SQ, and other routes as needed.


• Perform necropsy, tissue dissection, perfusion, and blood/tissue collection (in-life and terminal


• Perform blood collections via submandibular cheek bleeds and cardiac punctures.


• Prepare and process tissues for downstream analysis.


• Accurately label samples, track collection, and maintain comprehensive records.


• Follow protocols rigorously and contribute to protocol refinement when needed.


• Ability to follow SOPs and work independently in a high-throughput setting.


• Maintain accurate and organized data entry and analysis.


• Collaborate with cross-functional teams in a dynamic research environment.


• Strong attention to detail with excellent data organization and record keeping.


• Assist in maintaining inventories.

Required Qualifications

• Bachelors or Masters and 1-2+ years of experience (biotech/pharma industry preferred) in executing in vivo pharmacology experiments in mice


• Demonstrated expertise executing hands-on in vivo studies


• Collaborative, curious, and flexible with strong communication skills, both written and oral


• Self-motivated, highly organized,  able to work independently with minimal supervision, and able to multitask


• Strong attention to detail


• A genuine passion for science and developing medicines

Preferred Qualifications

• Familiarity with histology, microscopy, or tissue sectioning


• Experience in bioanalytical assays for protein therapeutics (PCR, nucleic acid extraction, ELISA, Western Blot, etc)


• Skilled with common data analysis and productivity software such as Microsoft Office, GraphPad Prism, and ImageJ.


• Experience  writing detailed research project plans and methodological SOPs that guide yours and other team members’ laboratory activities


• Experience in mouse health monitoring is highly preferred

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.