Scientist Biology (Screening)

We are seeking a highly skilled and motivated scientist with deep expertise in cancer biology, immunology, or rare disease research—ideally with experience in antibody-drug conjugates (ADCs) and/or PROTAC drug discovery. The successful candidate will join a multidisciplinary team to develop and characterize innovative therapeutic platforms. This role emphasizes functional and mechanistic studies, including ternary complex assays, biophysical and biochemical characterization, and the development of cell-based assays for drug candidate evaluation.

Responsibilities

• Design, develop, and execute cell-based and biochemical assays to evaluate the function, mechanism of action, and efficacy of ADCs, PROTACs, and other targeted therapeutics.


• Conduct ternary complex assays to characterize interactions among target proteins, E3 ligases, and PROTACs; assess formation, stability, and degradation efficiency.


• Apply surface plasmon resonance (SPR) and other biophysical techniques to study protein-protein and protein-small molecule interactions, including kinetic and cooperative binding analysis.


• Support PROTAC development through data-driven optimization of binding affinity, ternary complex formation, and degradation kinetics.


• Collaborate cross-functionally with pharmacology, DMPK, informatics, and predictive science teams to support lead selection and mechanism-of-action studies.


• Perform a wide range of lab techniques including tissue culture, qPCR, western blotting, ELISA, HiBit, and co-culture activity assays (2D/3D).


• Maintain rigorous documentation of experiments, analyze and interpret complex datasets, and present findings in internal meetings and reports.


• Contribute to expanding lab capabilities, identifying and implementing new technologies and assay platforms.


• Uphold high standards of laboratory safety and compliance.

Qualifications

• Strong background in cell biology, molecular biology, or biochemistry with a focus on oncology or immunology.


• Extensive hands-on experience with biochemical assays (e.g., SPR, ELISA), cell-based assays, and protein interaction studies.


• Proven expertise in ternary complex biology, PROTAC mechanism of action, and related protein degradation pathways.


• Familiarity with SPR, BLI, or other biophysical platforms for binding studies.


• Experience working with ADCs and/or PROTACs from discovery through early validation is highly desirable.


• Ability to execute and troubleshoot experiments independently, and to analyze complex datasets in context.


• Excellent organizational, interpersonal, and communication skills—capable of cross-functional collaboration in a fast-paced biotech environment.


• A proactive, innovative mindset with a strong interest in advancing novel therapeutic platforms.

Education-
BS with +15 year, MS with 10+ years or PhD with up to 5 years of relevant industry experience in drug discovery.

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 *U.S. citizens and those authorized to work in the U.S. (green card) are encouraged to apply. We are unable to sponsor at this time. 

*Candidate must be able to pass a background investigation. 

*Unable to work with 3rd party candidates or agencies. 

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily within the context of the representative work environment and physical demands described above. Likewise, qualifications listed are representative of the knowledge, skills, and abilities required to perform the position’s essential functions. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. 

Orum Therapeutics is an Equal Opportunity Employer (EOE).