Scientist, Genome Engineering

We are looking for a talented Scientist with knowledge and passion for ambitious synthetic biology projects and large-scale genome engineering for species conservation and de-extinction. We will be building tools and methodologies for engineering various cell types, and will develop workflows to manipulate large DNA fragments and genomes. The candidate will work with a talented group of engineers and biologists committed to developing novel conservation technologies that will change the world.

This position is based in Dallas, TX. Relocation assistance is available.

Duties/Responsibilities:

• Design, innovate and iterate: DNA assembly, integration, editing and screening


• Build enabling molecular and cellular tools


• Perform DNA/RNA transfections and/or viral transductions


• Quantify genome editing events using various molecular assays


• Data analysis, figure generation and timely reporting of results


• Present findings at small forums and R&D meetings


• Maintain a thorough and detailed electronic lab notebook


• Maintain a clean and organized laboratory space

Basic Qualifications:

• PhD/MS in synthetic biology, bioengineering, molecular biology, genetics or related field is required, or 3+ years hands-on expertise in genetics and genomic manipulation


• Solid understanding and hands-on experience with current editing techniques


• Experience with cell culture, DNA/RNA transfection, bacterial culture, recombinant DNA cloning techniques, primer design and PCR, gel electrophoresis, nucleic acid extraction and purification


• Self-motivated, proactive, works well under pressure and deadlines, detail oriented


• Enthusiasm for learning new skills and taking on new responsibilities


• Strong written and oral communication skills, as well as creative problem-solving skills


• Enjoys the fast-paced startup environment and teamwork

Preferred Qualifications:

• High throughput screening experience or automation methods


• NGS library prep, immunostaining and flow cytometry experience


• Current experience with next-generation editing tools

What Colossal Offers Full-Time Employees:

• Medical, dental, and vision coverage


• Excellent paid time off and company holidays so you can rest and recharge 


• Flexible spending accounts (FSA)


• Company matched 401k retirement plan


• Paid parental leave at 100% salary for up to 12 weeks


• Education reimbursement 


• An opportunity to help us return the Earth to a healthier state

The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. 

Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.

Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. 

EEO is the Law 

Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. 

Colossal is proud to be named a Best Place to Work by BuiltIn for 4 years in a row across multiple categories in 2023, 2024, 2025, and 2026:

• #1 on the 50 Best Startups to Work For in Dallas in 2023!


• 100 Best Midsize Places to Work in Dallas in 2024 & 2025


• 100 Best Places to Work in Dallas, TX (All Size Employers) in 2024, 2025, and 2026.

Built In 2026 Award Lists

Great Place to Work Certification Page

Most Loved Workplace Certification Page - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.

Newsweek's Most Loved Workplaces 2024 Award List - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!