Scientist II - Oligonucleotides

Our client, leading
leader in biotechnology and diagnostics, is looking for Scientist II - Oligonucleotides based
out of South San Francisco. If you are interested to discuss
further, please review the details below.

Duration: Long term
contract (Possibility of further extension)

Pay Rate: $53.50/hr on W2

Job Summary:

• Perform hands-on synthesis, purification, and characterization of oligonucleotides using automated synthesizers, HPLC, and mass spectrometry.
  
• Develop, optimize, and troubleshoot oligonucleotide synthesis methods, including impurity profiling and process improvements.
  
• Collaborate with cross-functional research teams to support oligonucleotide therapeutic discovery and lead molecule progression.
  
• Operate, maintain, and troubleshoot laboratory equipment including oligo synthesizers, HPLC systems, and desalting units.
  
• Execute nucleic acid chemistry experiments, analyze data, maintain laboratory documentation, and support scale-up synthesis for preclinical studies.
  
• Conduct literature reviews and contribute to experimental planning, scientific discussions, and project presentations.
  
• Maintain high laboratory productivity while adhering to safety and quality standards.
  

• BS or MS in Organic Chemistry, Medicinal Chemistry, Biochemistry, Chemical Biology, or a related scientific discipline.
  
• Hands-on experience with automated oligonucleotide synthesis.
  
• Experience with HPLC purification and mass spectrometry for oligonucleotide characterization.
  
• Knowledge of nucleic acid chemistry and oligonucleotide synthesis workflows.
  
• Strong analytical, troubleshooting, organizational, and communication skills.
  
• Ability to work independently and collaboratively in a fast-paced research environment.
  

• Experience in RNAi therapeutics, antisense oligonucleotides (ASO), or nucleic acid therapeutics.
  
• Experience with large molecule drug discovery, oligonucleotide delivery, or bioconjugation.
  
• Knowledge of sequence design, nucleic acid modifications, and therapeutic mechanisms of action.
  
• Pharmaceutical or biotechnology industry experience in oligonucleotide drug discovery.
  
• Experience supporting preclinical research and scale-up synthesis.
  

• Oligonucleotide Synthesis
  
• Automated Oligo Synthesizers
  
• RNAi / RNA Therapeutics
  
• Nucleic Acid Chemistry
  
• HPLC Purification
  
• Mass Spectrometry (LC-MS)
  
• Oligonucleotide Characterization
  
• Impurity Profiling & Troubleshooting
  
• Organic Synthesis
  

If interested, please
send your updated resume at [email protected]/[email protected]