Scientist II Oligonuleotide Synthesis

Our client, a world
leader in biotechnology and gene therapy, is looking for an “Scientist
II – Oligonuleotide Synthesis” based in South San Francisco, CA.

Job Duration: Long
Term Contract (Possibility Of Extension)

Pay Rate : $53/hr on W2

Company Benefits: Medical, Dental,
Vision, Paid Sick leave, 401K

We are seeking a Scientist
II to join the Nucleic Acid Design and Discovery (NADD) team. This
role focuses on oligonucleotide therapeutics discovery, supporting
RNAi-based research through synthesis, characterization, and collaboration
across therapeutic areas.

Key Responsibilities

• Design
  and execute oligonucleotide synthesis and purification workflows.
  
• Perform
  HPLC and mass spectrometry analysis for characterization and impurity
  profiling.
  
• Support
  RNAi and nucleic acid therapeutic discovery across neuroscience,
  immunology, and oncology programs.
  
• Develop
  and scale up synthesis of lead oligonucleotide candidates for preclinical
  studies.
  
• Collaborate
  with cross-functional teams to integrate chemistry and biology data.
  
• Maintain
  and troubleshoot lab equipment (e.g., oligo synthesizers, HPLC systems).
  
• Conduct
  literature reviews and contribute to experimental design and strategy.
  

Qualifications:

• BS/MS
  in Organic Chemistry or related field.
  
• Hands-on
  experience with oligonucleotide synthesis, purification, and
  characterization.
  
• Experience
  with automated oligo synthesizers, HPLC, and mass spectrometry.
  
• Understanding
  of RNAi, nucleic acid therapeutics, and modification chemistries
  preferred.
  
• Industry
  experience in biotech/pharma R&D is a plus.
  

If interested, please
send us your updated resume at

[email protected]/[email protected]